deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 1-arm NCT05162976

CC-486 and Nivolumab for the Treatment of Hodgkin Lymphoma Refractory to PD-1 Therapy or Relapsed

A Phase 1 Study of CC-486 Plus Nivolumab in Patients With Hodgkin Lymphoma Refractory to PD-1 Therapy

Sponsor: City of Hope Medical Center

Updated 10 times since 2022 Last updated: Jun 13, 2025 Started: Jan 3, 2022 Primary completion: May 12, 2026 Completion: May 12, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Recurrent Classic Hodgkin Lymphoma and Refractory Classic Hodgkin Lymphoma and is currently ongoing. City of Hope Medical Center leads this study, which shows 10 recorded versions since 2022 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2022 – ~Apr 2022 · 3 months · monthly snapshotRecruiting~Apr 2022 – ~Apr 2023 · 12 months · monthly snapshotRecruiting~Apr 2023 – ~Jul 2023 · 3 months · monthly snapshotRecruiting~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshotActive Not Recruiting~Aug 2023 – ~Feb 2024 · 6 months · monthly snapshotRecruiting~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshotRecruiting~Oct 2024 – ~Jul 2025 · 9 months · monthly snapshotActive Not Recruiting~Jul 2025 – present · 14 months · monthly snapshotActive Not Recruiting

Change History

10 versions recorded
  1. Jul 2025 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Oct 2024 — Jul 2025 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  3. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  5. Feb 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

Show 5 earlier versions
  1. Aug 2023 — Feb 2024 [monthly]

    Recruiting PHASE1

    Status: Active Not RecruitingRecruiting

  2. Jul 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  3. Apr 2023 — Jul 2023 [monthly]

    Recruiting PHASE1

  4. Apr 2022 — Apr 2023 [monthly]

    Recruiting PHASE1

  5. Jan 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • City of Hope Medical Center
  • National Cancer Institute (NCI)
Data source: City of Hope Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations