deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 1-arm NCT05185843

A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRX) Administered to Adults With Familial Chylomicronemia Syndrome (FCS) Previously Treated With Volanesorsen

An Open-Label Safety Study of AKCEA-APOCIII-LRX Administered Subcutaneously to Patients With Familial Chylomicronemia Syndrome (FCS) Previously Treated With Volanesorsen (ISIS 304801)

Sponsor: Ionis Pharmaceuticals, Inc.

Interventions Olezarsen
Updated 14 times since 2022 Last updated: Dec 5, 2025 Started: Feb 25, 2022 Primary completion: Jun 30, 2027 Completion: Jun 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Familial Chylomicronemia Syndrome, this trial is ongoing. The trial is conducted by Ionis Pharmaceuticals, Inc. and has accumulated 14 data snapshots since 2022. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Jul 2023 · 10 months · monthly snapshot~Jul 2023 – ~Sep 2023 · 2 months · monthly snapshot~Sep 2023 – ~Jun 2024 · 9 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Jan 2026 · 12 months · monthly snapshot~Jan 2026 – present · 7 months · monthly snapshot

Change History

14 versions recorded
  1. Jan 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Jan 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE3

Show 9 earlier versions
  1. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  2. Sep 2023 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  3. Jul 2023 — Sep 2023 [monthly]

    Recruiting PHASE3

  4. Sep 2022 — Jul 2023 [monthly]

    Recruiting PHASE3

  5. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  6. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  7. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  8. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  9. Feb 2022 — Apr 2022 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Ionis Pharmaceuticals, Inc.
Data source: Ionis Pharmaceuticals, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .