deltatrials
Completed PHASE1 INTERVENTIONAL 7-arm NCT05293496

A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors

A Phase 1/1b Dose Escalation and Cohort Expansion Study of MGC018 in Combination With Checkpoint Inhibitor in Participants With Advanced Solid Tumors

Sponsor: MacroGenics

Updated 16 times since 2022 Last updated: Oct 9, 2025 Started: Apr 19, 2022 Primary completion: Jun 24, 2025 Completion: Aug 26, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05293496, this PHASE1 trial focuses on Advanced Solid Tumor and Castration-Resistant Prostatic Cancer and remains completed. Sponsored by MacroGenics, it has been updated 16 times since 2022, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Feb 2024 · 6 months · monthly snapshotRecruiting~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Jun 2025 · 6 months · monthly snapshotActive Not Recruiting~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Nov 2025 · 3 months · monthly snapshot~Nov 2025 – present · 9 months · monthly snapshotCompleted

Change History

16 versions recorded
  1. Nov 2025 — Present [monthly]

    Completed PHASE1

    Status: Active Not RecruitingCompleted

  2. Aug 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Jun 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Dec 2024 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  5. Sep 2024 — Dec 2024 [monthly]

    Recruiting PHASE1

Show 11 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  2. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  3. Feb 2024 — Apr 2024 [monthly]

    Recruiting PHASE1

  4. Aug 2023 — Feb 2024 [monthly]

    Recruiting PHASE1

  5. Jun 2023 — Aug 2023 [monthly]

    Recruiting PHASE1

  6. Apr 2023 — Jun 2023 [monthly]

    Recruiting PHASE1

  7. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE1

  8. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE1

  9. Sep 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  10. Jun 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  11. Apr 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • MacroGenics
Data source: MacroGenics

For direct contact, visit the study record on ClinicalTrials.gov .