deltatrials
Recruiting PHASE3 INTERVENTIONAL 2-arm NCT05303064

Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder

A Phase 3, Randomized, Double-Blind, 52-Week Study of OLZ/SAM vs Olanzapine to Evaluate Weight Gain as Assessed by Change in BMI Z-Score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder (ENLIGHTEN-Youth)

Sponsor: Alkermes, Inc.

Updated 20 times since 2022 Last updated: Feb 17, 2026 Started: Jun 30, 2022 Primary completion: Sep 30, 2026 Completion: Sep 30, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Bipolar I Disorder and Schizophrenia and is currently actively recruiting participants. Alkermes, Inc. leads this study, which shows 20 recorded versions since 2022 — indicating substantial longitudinal coverage. This study adds to the longitudinal dataset for psychiatric treatment development.

Status Flow

~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Oct 2022 · 30 days · monthly snapshot~Oct 2022 – ~Dec 2022 · 2 months · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jul 2023 · 3 months · monthly snapshot~Jul 2023 – ~Dec 2023 · 5 months · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~May 2024 · 4 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Mar 2025 · 4 months · monthly snapshot~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Aug 2025 · 3 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Feb 2026 · 3 months · monthly snapshot~Feb 2026 – present · 3 months · monthly snapshot

Change History

20 versions recorded
  1. Feb 2026 — Present [monthly]

    Recruiting PHASE3

  2. Nov 2025 — Feb 2026 [monthly]

    Recruiting PHASE3

  3. Sep 2025 — Nov 2025 [monthly]

    Recruiting PHASE3

  4. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE3

  5. May 2025 — Aug 2025 [monthly]

    Recruiting PHASE3

Show 15 earlier versions
  1. Mar 2025 — May 2025 [monthly]

    Recruiting PHASE3

  2. Nov 2024 — Mar 2025 [monthly]

    Recruiting PHASE3

  3. Sep 2024 — Nov 2024 [monthly]

    Recruiting PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  5. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE3

  6. Jan 2024 — May 2024 [monthly]

    Recruiting PHASE3

  7. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE3

  8. Jul 2023 — Dec 2023 [monthly]

    Recruiting PHASE3

  9. Apr 2023 — Jul 2023 [monthly]

    Recruiting PHASE3

  10. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  11. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE3

  12. Oct 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  13. Sep 2022 — Oct 2022 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  14. Jun 2022 — Sep 2022 [monthly]

    Not Yet Recruiting PHASE3

  15. Apr 2022 — Jun 2022 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Alkermes, Inc.
Data source: Alkermes, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .