deltatrials
Terminated PHASE2 INTERVENTIONAL 1-arm NCT05350501

EO2040 in Combination With Nivolumab, for Treatment of Patients With Minimal Residual Disease of Colorectal Cancer (CLAUDE)

A Phase 2 Trial of EO2040, a miCrobiaL-derived Peptide therApeUtic Vaccine, in Combination With Nivolumab, for Treatment of Patients With ctDNA-dEfined Minimal Residual Disease of CRC Stage II, III, or IV After Curative Therapy

Sponsor: Enterome

Interventions EO2040
Updated 12 times since 2022 Last updated: Sep 15, 2025 Started: Mar 1, 2023 Primary completion: Jan 23, 2024 Completion: Jan 23, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

the study recruitment is significantly behind expectations as only one single patient has started treatment

A PHASE2 clinical study on Colorectal Cancer, this trial is terminated or withdrawn. The trial is conducted by Enterome and has accumulated 12 data snapshots since 2023. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~May 2022 – ~Nov 2022 · 6 months · monthly snapshotNot Yet Recruiting~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshotNot Yet Recruiting~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshotRecruiting~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshotRecruiting~Apr 2023 – ~Aug 2023 · 4 months · monthly snapshotRecruiting~Aug 2023 – ~Apr 2024 · 8 months · monthly snapshotRecruiting~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshotCompleted~Jan 2025 – ~Jul 2025 · 6 months · monthly snapshotTerminated~Jul 2025 – ~Oct 2025 · 3 months · monthly snapshotTerminated~Oct 2025 – present · 8 months · monthly snapshotTerminated

Change History

12 versions recorded
  1. Oct 2025 — Present [monthly]

    Terminated PHASE2

  2. Jul 2025 — Oct 2025 [monthly]

    Terminated PHASE2

  3. Jan 2025 — Jul 2025 [monthly]

    Terminated PHASE2

    Status: CompletedTerminated

  4. Sep 2024 — Jan 2025 [monthly]

    Completed PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

Show 7 earlier versions
  1. Apr 2024 — Jul 2024 [monthly]

    Completed PHASE2

    Status: RecruitingCompleted

  2. Aug 2023 — Apr 2024 [monthly]

    Recruiting PHASE2

  3. Apr 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  4. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  5. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  6. Nov 2022 — Feb 2023 [monthly]

    Not Yet Recruiting PHASE2

  7. May 2022 — Nov 2022 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Enterome
Data source: Enterome

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations