Active Not Recruiting OBSERVATIONAL NCT05364086

An Observational Research Study for Cancer Patients on Immune Checkpoint Inhibitors, DiRECT Study (DiRECT)

Disparities in Results of Immune Checkpoint Inhibitor Treatment (DiRECT): A Prospective Cohort Study of Cancer Survivors Treated With Anti-PD-1/Anti-PD-L1 Immunotherapy in a Community Oncology Setting

Sponsor: National Cancer Institute (NCI)

Conditions Hematopoietic and Lymphoid Cell Neoplasm Malignant Solid Neoplasm

Interventions Biospecimen Collection Electronic Health Record Review Interview Quality-of-Life Assessment Questionnaire Administration

Updated 8 times since 2022 Last updated: Mar 11, 2026 Started: Apr 26, 2022 Primary completion: Oct 31, 2026 Completion: Jan 31, 2030

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05364086, this observational or N/A phase trial focuses on Hematopoietic and Lymphoid Cell Neoplasm and Malignant Solid Neoplasm and remains ongoing. Sponsored by National Cancer Institute (NCI), it has been updated 8 times since 2022, reflecting limited change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

8 versions recorded

Mar 2026 — Present [monthly]

Active Not Recruiting

Status: Recruiting → Active Not Recruiting
Sep 2025 — Mar 2026 [monthly]

Recruiting
Jun 2025 — Sep 2025 [monthly]

Recruiting
Sep 2024 — Jun 2025 [monthly]

Recruiting
Jul 2024 — Sep 2024 [monthly]

Recruiting

▶ Show 3 earlier versions

May 2024 — Jul 2024 [monthly]

Recruiting
Jul 2023 — May 2024 [monthly]

Recruiting
Jun 2022 — Jul 2023 [monthly]

Recruiting

First recorded

Apr 2022

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

National Cancer Institute (NCI)
University of Rochester NCORP Research Base

Data source: University of Rochester

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Alexandria, United States , Allentown, United States , Alton, United States , Anaheim, United States , Anderson, United States , Ann Arbor, United States , Antioch, United States , Appleton, United States , Asheville, United States , Atlanta, United States and 190 more locations