deltatrials
Terminated PHASE2/PHASE3 INTERVENTIONAL 1-arm NCT05366751

A Study to Evaluate the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor

An Open-label Study of the Long-term Safety and Tolerability of SAGE-324 in Participants With Essential Tremor

Sponsor: Sage Therapeutics

Interventions SAGE-324
Updated 12 times since 2022 Last updated: Jul 15, 2025 Started: Jun 3, 2022 Primary completion: Sep 10, 2024 Completion: Sep 10, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Internal company decision

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This PHASE2/PHASE3 trial investigates Essential Tremor and is currently terminated or withdrawn. Sage Therapeutics leads this study, which shows 12 recorded versions since 2022 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshotNot Yet Recruiting~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshotRecruiting~Jan 2023 – ~May 2023 · 4 months · monthly snapshotRecruiting~May 2023 – ~Jul 2023 · 2 months · monthly snapshotRecruiting~Jul 2023 – ~Sep 2023 · 2 months · monthly snapshotRecruiting~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshotRecruiting~Oct 2023 – ~Jun 2024 · 8 months · monthly snapshotRecruiting~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshotActive Not Recruiting~Nov 2024 – ~Sep 2025 · 10 months · monthly snapshotTerminated~Sep 2025 – present · 10 months · monthly snapshotTerminated

Change History

12 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE2/PHASE3

  2. Nov 2024 — Sep 2025 [monthly]

    Terminated PHASE2/PHASE3

    Status: Active Not RecruitingTerminated

  3. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2/PHASE3

    Status: RecruitingActive Not Recruiting

  4. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2/PHASE3

    Phase: PHASE2_PHASE3PHASE2/PHASE3

  5. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE2_PHASE3

Show 7 earlier versions
  1. Oct 2023 — Jun 2024 [monthly]

    Recruiting PHASE2_PHASE3

  2. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE2_PHASE3

  3. Jul 2023 — Sep 2023 [monthly]

    Recruiting PHASE2_PHASE3

  4. May 2023 — Jul 2023 [monthly]

    Recruiting PHASE2_PHASE3

    Phase: PHASE2PHASE2_PHASE3

  5. Jan 2023 — May 2023 [monthly]

    Recruiting PHASE2

  6. Sep 2022 — Jan 2023 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  7. Jun 2022 — Sep 2022 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Sage Therapeutics
Data source: Sage Therapeutics

For direct contact, visit the study record on ClinicalTrials.gov .