deltatrials
Active Not Recruiting EARLY_PHASE1 INTERVENTIONAL 1-arm NCT05469009

Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for Mild Cognitive Impairment or Mild Alzheimer's Disease Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy

Assessment of Safety and Feasibility of Exablate Blood-Brain Barrier Disruption for the Treatment of Patients With With Mild Cognitive Impairment (MCI) or Mild Alzheimer's Disease (AD) Undergoing Standard of Care Monoclonal Antibody (mAb) Therapy

Sponsor: Ali Rezai

Updated 9 times since 2022 Last updated: Jan 21, 2026 Started: Jul 14, 2022 Primary completion: Jul 31, 2029 Completion: Jul 31, 2029
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This EARLY_PHASE1 trial investigates Alzheimer Disease 1 and Mild Cognitive Impairment and is currently ongoing. Ali Rezai leads this study, which shows 9 recorded versions since 2022 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2022 – ~Jan 2024 · 16 months · monthly snapshotRecruiting~Jan 2024 – ~Mar 2024 · 2 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshotRecruiting~Apr 2025 – ~Jun 2025 · 2 months · monthly snapshot~Jun 2025 – ~Oct 2025 · 4 months · monthly snapshotRecruiting~Oct 2025 – ~Feb 2026 · 4 months · monthly snapshotActive Not Recruiting~Feb 2026 – present · 5 months · monthly snapshotActive Not Recruiting

Change History

9 versions recorded
  1. Feb 2026 — Present [monthly]

    Active Not Recruiting EARLY_PHASE1

  2. Oct 2025 — Feb 2026 [monthly]

    Active Not Recruiting EARLY_PHASE1

    Status: RecruitingActive Not Recruiting

  3. Jun 2025 — Oct 2025 [monthly]

    Recruiting EARLY_PHASE1

  4. Apr 2025 — Jun 2025 [monthly]

    Recruiting EARLY_PHASE1

  5. Sep 2024 — Apr 2025 [monthly]

    Recruiting EARLY_PHASE1

Show 4 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting EARLY_PHASE1

  2. Mar 2024 — Jul 2024 [monthly]

    Recruiting EARLY_PHASE1

  3. Jan 2024 — Mar 2024 [monthly]

    Recruiting EARLY_PHASE1

  4. Sep 2022 — Jan 2024 [monthly]

    Recruiting EARLY_PHASE1

    First recorded

Jul 2022

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Ali Rezai
  • InSightec
Data source: West Virginia University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations