Completed NA INTERVENTIONAL 2-arm NCT05525013

Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8

Effect of Simvastatin Versus Calcium Hydroxide Used as Intracanal Medicaments on Post-operative Pain and Total Amount of IL-6 and IL-8 in Periapical Fluids in Patients With Symptomatic Apical Periodontitis: A Randomized Clinical Trial

Sponsor: Cairo University

Conditions Periapical Periodontitis

Interventions Calcium Hydroxide Simvastatin Powder

Updated 7 times since 2022 Last updated: Jun 10, 2025 Started: Oct 1, 2022 Primary completion: Jun 1, 2024 Completion: Jul 1, 2024

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates Periapical Periodontitis and is currently completed. Cairo University leads this study, which shows 7 recorded versions since 2022 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

7 versions recorded

Jul 2025 — Present [monthly]

Completed NA
Feb 2025 — Jul 2025 [monthly]

Completed NA

Status: Recruiting → Completed
Sep 2024 — Feb 2025 [monthly]

Recruiting NA
Jul 2024 — Sep 2024 [monthly]

Recruiting NA
Mar 2024 — Jul 2024 [monthly]

Recruiting NA

▶ Show 2 earlier versions

Dec 2022 — Mar 2024 [monthly]

Recruiting NA

Status: Not Yet Recruiting → Recruiting
Sep 2022 — Dec 2022 [monthly]

Not Yet Recruiting NA

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Cairo University

Data source: Cairo University

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Cairo, Egypt