deltatrials
Recruiting PHASE1 INTERVENTIONAL 4-arm NCT05557292

RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma

A Phase I/Ib, Open-Label, Dose-Escalation Study of RMC-5552 Monotherapy in Adult Subjects With Recurrent Glioblastoma

Sponsor: National Cancer Institute (NCI)

Interventions RMC-5552
Updated 12 times since 2022 Last updated: Sep 15, 2025 Started: Apr 3, 2023 Primary completion: Apr 30, 2030 Completion: Apr 30, 2030
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05557292, this PHASE1 trial focuses on Glioblastoma and Recurrent Glioblastoma and remains actively recruiting participants. Sponsored by National Cancer Institute (NCI), it has been updated 12 times since 2023, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshotNot Yet Recruiting~Dec 2022 – ~Mar 2023 · 3 months · monthly snapshotNot Yet Recruiting~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshotNot Yet Recruiting~Apr 2023 – ~May 2023 · 30 days · monthly snapshotNot Yet Recruiting~May 2023 – ~Nov 2023 · 6 months · monthly snapshotRecruiting~Nov 2023 – ~May 2024 · 6 months · monthly snapshotActive Not Recruiting~May 2024 – ~Jul 2024 · 2 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshotRecruiting~Dec 2024 – ~May 2025 · 5 months · monthly snapshotRecruiting~May 2025 – ~Oct 2025 · 5 months · monthly snapshotSuspended~Oct 2025 – present · 9 months · monthly snapshotRecruiting

Change History

12 versions recorded
  1. Oct 2025 — Present [monthly]

    Recruiting PHASE1

    Status: SuspendedRecruiting

  2. May 2025 — Oct 2025 [monthly]

    Suspended PHASE1

    Status: RecruitingSuspended

  3. Dec 2024 — May 2025 [monthly]

    Recruiting PHASE1

  4. Sep 2024 — Dec 2024 [monthly]

    Recruiting PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

Show 7 earlier versions
  1. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

    Status: Active Not RecruitingRecruiting

  2. Nov 2023 — May 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  3. May 2023 — Nov 2023 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  4. Apr 2023 — May 2023 [monthly]

    Not Yet Recruiting PHASE1

  5. Mar 2023 — Apr 2023 [monthly]

    Not Yet Recruiting PHASE1

  6. Dec 2022 — Mar 2023 [monthly]

    Not Yet Recruiting PHASE1

  7. Sep 2022 — Dec 2022 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
  • Nicholas Butowski
  • Revolution Medicines, Inc.
Data source: University of California, San Francisco

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations