deltatrials
Terminated PHASE1 INTERVENTIONAL 2-arm NCT05623488

CAR T Cells in Mesothelin-Expressing Breast Cancer

Phase 1, Adaptive-design Trial of Human Chimeric Antigen Receptor Modified T Cells in Patients With Mesothelin Expressing Breast Cancer

Sponsor: University of Pennsylvania

Conditions Breast Cancer
Updated 12 times since 2022 Last updated: Aug 6, 2025 Started: Feb 6, 2023 Primary completion: Apr 7, 2025 Completion: Apr 7, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Feasibility Concerns

This PHASE1 trial investigates Breast Cancer and is currently terminated or withdrawn. University of Pennsylvania leads this study, which shows 12 recorded versions since 2023 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshotNot Yet Recruiting~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshotNot Yet Recruiting~Mar 2023 – ~Jul 2023 · 4 months · monthly snapshotRecruiting~Jul 2023 – ~Feb 2024 · 7 months · monthly snapshotRecruiting~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshotRecruiting~Feb 2025 – ~Apr 2025 · 59 days · monthly snapshotRecruiting~Apr 2025 – ~Jun 2025 · 2 months · monthly snapshotActive Not Recruiting~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshotTerminated~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshotTerminated~Sep 2025 – present · 12 months · monthly snapshotTerminated

Change History

12 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE1

  2. Jul 2025 — Sep 2025 [monthly]

    Terminated PHASE1

  3. Jun 2025 — Jul 2025 [monthly]

    Terminated PHASE1

    Status: Active Not RecruitingTerminated

  4. Apr 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  5. Feb 2025 — Apr 2025 [monthly]

    Recruiting PHASE1

Show 7 earlier versions
  1. Sep 2024 — Feb 2025 [monthly]

    Recruiting PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  3. Feb 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  4. Jul 2023 — Feb 2024 [monthly]

    Recruiting PHASE1

  5. Mar 2023 — Jul 2023 [monthly]

    Recruiting PHASE1

    Status: Not Yet RecruitingRecruiting

  6. Feb 2023 — Mar 2023 [monthly]

    Not Yet Recruiting PHASE1

  7. Dec 2022 — Feb 2023 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • University of Pennsylvania
Data source: University of Pennsylvania

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations