deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT03225547

Study of Pembrolizumab and Mifepristone in Patients With Advanced HER2-negative Breast Cancer

Phase II Study of Pembrolizumab and Mifepristone in Patients With Advanced HER2-negative Breast Cancer

Sponsor: University of Chicago

Updated 14 times since 2017 Last updated: Dec 19, 2025 Started: Feb 12, 2018 Primary completion: Sep 30, 2025 Completion: Sep 30, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

side effects (rash)

A PHASE2 clinical study on Breast Cancer and Triple Negative Breast Neoplasms, this trial is terminated or withdrawn. The trial is conducted by University of Chicago and has accumulated 14 data snapshots since 2018. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Aug 2017 – ~Mar 2018 · 7 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Nov 2019 · 17 months · monthly snapshot~Nov 2019 – ~Oct 2020 · 11 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~May 2023 · 17 months · monthly snapshot~May 2023 – ~Jul 2024 · 14 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2025 · 14 months · monthly snapshot~Nov 2025 – ~Jan 2026 · 2 months · monthly snapshot~Jan 2026 – present · 6 months · monthly snapshot

Change History

14 versions recorded
  1. Jan 2026 — Present [monthly]

    Terminated PHASE2

    Status: Active Not RecruitingTerminated

  2. Nov 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2024 — Nov 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE2

Show 9 earlier versions
  1. May 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Dec 2021 — May 2023 [monthly]

    Active Not Recruiting PHASE2

  3. Oct 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  4. Jan 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  5. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Active Not RecruitingRecruiting

  6. Nov 2019 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  7. Jun 2018 — Nov 2019 [monthly]

    Recruiting PHASE2

  8. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  9. Aug 2017 — Mar 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • University of Chicago
Data source: University of Chicago

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations