deltatrials
Completed PHASE2 INTERVENTIONAL 4-arm NCT05660538

Evaluation of Efficacy and Safety of VX-548 for Painful Diabetic Peripheral Neuropathy (DPN)

A Phase 2, Randomized, Double-blind, Active-controlled, Dose-ranging, Parallel-design Study of the Efficacy and Safety of VX-548 in Subjects With Painful Diabetic Peripheral Neuropathy

Sponsor: Vertex Pharmaceuticals Incorporated

Updated 17 times since 2023 Last updated: Jun 13, 2025 Started: Dec 20, 2022 Primary completion: Oct 12, 2023 Completion: Oct 25, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Diabetic Peripheral Neuropathy and is currently completed. Vertex Pharmaceuticals Incorporated leads this study, which shows 17 recorded versions since 2022 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Sep 2023 · 2 months · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Aug 2025 · 9 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

17 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Aug 2025 — Sep 2025 [monthly]

    Completed PHASE2

  3. Nov 2024 — Aug 2025 [monthly]

    Completed PHASE2

  4. Sep 2024 — Nov 2024 [monthly]

    Completed PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

Show 12 earlier versions
  1. Apr 2024 — Jul 2024 [monthly]

    Completed PHASE2

  2. Feb 2024 — Apr 2024 [monthly]

    Completed PHASE2

  3. Dec 2023 — Feb 2024 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  4. Oct 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  6. Jul 2023 — Sep 2023 [monthly]

    Recruiting PHASE2

  7. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE2

  8. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE2

  9. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2

  10. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  11. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

    Status: Not Yet RecruitingRecruiting

  12. Jan 2023 — Feb 2023 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Dec 2022

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Vertex Pharmaceuticals Incorporated
Data source: Vertex Pharmaceuticals Incorporated

For direct contact, visit the study record on ClinicalTrials.gov .