Completed OBSERVATIONAL NCT05893173

Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Sleep Deprivation

Pilot Study: Establishing Glutamatergic Changes as the Mechanism of Action in the Rapid Antidepressant Effects of Sleep Deprivation

Sponsor: University of Pennsylvania

Conditions Major Depressive Disorder

Interventions Sleep Deprivation

Updated 6 times since 2023 Last updated: Feb 25, 2025 Started: Jun 19, 2023 Primary completion: Feb 2, 2025 Completion: Feb 2, 2025

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This observational or N/A phase trial investigates Major Depressive Disorder and is currently completed. University of Pennsylvania leads this study, which shows 6 recorded versions since 2023 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

6 versions recorded

Mar 2025 — Present [monthly]

Completed

Status: Recruiting → Completed
Sep 2024 — Mar 2025 [monthly]

Recruiting
Aug 2024 — Sep 2024 [monthly]

Recruiting
Jul 2024 — Aug 2024 [monthly]

Recruiting
Aug 2023 — Jul 2024 [monthly]

Recruiting

Status: Not Yet Recruiting → Recruiting

▶ Show 1 earlier version

Jul 2023 — Aug 2023 [monthly]

Not Yet Recruiting

First recorded

Jun 2023

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

University of Pennsylvania

Data source: University of Pennsylvania

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Philadelphia, United States