A Study of Bomedemstat (IMG-7289/MK-3543) Compared to Best Available Therapy (BAT) in Participants With Essential Thrombocythemia and an Inadequate Response or Intolerance of Hydroxyurea (MK-3543-006)
A Phase 3, Randomized, Open-label, Active-Comparator-Controlled Clinical Study to Evaluate the Safety and Efficacy of Bomedemstat (MK-3543/IMG-7289) Versus Best Available Therapy (BAT) in Participants With Essential Thrombocythemia Who Have an Inadequate Response to or Are Intolerant of Hydroxyurea
Sponsor: Merck Sharp & Dohme LLC
A observational or N/A phase clinical study on Essential Thrombocythemia, this trial is actively recruiting participants. The trial is conducted by Merck Sharp & Dohme LLC and has accumulated 29 data snapshots since 2023. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.
Status Flow
Change History
29 versions recorded-
May 4, 2026 — Present [daily]
Recruiting
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Apr 28, 2026 — May 4, 2026 [daily]
Recruiting
Phase: PHASE3 → None
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Mar 2026 — Apr 2026 [monthly]
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Feb 2026 — Mar 2026 [monthly]
Recruiting PHASE3
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Jan 2026 — Feb 2026 [monthly]
Recruiting PHASE3
▶ Show 24 earlier versions
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Dec 2025 — Jan 2026 [monthly]
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Recruiting PHASE3
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Oct 2025 — Nov 2025 [monthly]
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Dec 2024 — Jan 2025 [monthly]
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Oct 2024 — Dec 2024 [monthly]
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Jun 2024 — Jul 2024 [monthly]
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May 2024 — Jun 2024 [monthly]
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Apr 2024 — May 2024 [monthly]
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Mar 2024 — Apr 2024 [monthly]
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Feb 2024 — Mar 2024 [monthly]
Recruiting PHASE3
Status: Not Yet Recruiting → Recruiting
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Dec 2023 — Feb 2024 [monthly]
Not Yet Recruiting PHASE3
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Nov 2023 — Dec 2023 [monthly]
Not Yet Recruiting PHASE3
First recorded
Eligibility Summary
This is a study evaluating the safety and efficacy of bomedemstat (MK-3543) compared with the best available therapy (BAT) in participants with essential thrombocythemia (ET) who have an inadequate response to or are intolerant of hydroxyurea. The primary study hypothesis is that bomedemstat is superior to the best available therapy with respect to durable clinicohematologic response (DCHR).
Contact Information
- Merck Sharp & Dohme LLC
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
ABB, Argentina , Aachen, Germany , Adelaide, Australia , Albacete, Spain , Alessandria, Italy , Ancona, Italy , Ankara, Turkey (Türkiye) , Ankara, Turkey (Türkiye) , Ankara, Turkey (Türkiye) , Ann Arbor, United States and 153 more locations