Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT06347133

Phase 3 Study of Plozasiran in Adults With Hypertriglyceridemia (MUIR-3)

Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults With Hypertriglyceridemia

Sponsor: Arrowhead Pharmaceuticals

Conditions Hypertriglyceridemia

Interventions Placebo Plozasiran Injection

Updated 13 times since 2024 Last updated: Oct 3, 2025 Started: May 21, 2024 Primary completion: May 31, 2026 Completion: Sep 30, 2026

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Hypertriglyceridemia and is currently ongoing. Arrowhead Pharmaceuticals leads this study, which shows 13 recorded versions since 2024 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

13 versions recorded

Nov 2025 — Present [monthly]

Active Not Recruiting PHASE3
Oct 2025 — Nov 2025 [monthly]

Active Not Recruiting PHASE3
Sep 2025 — Oct 2025 [monthly]

Active Not Recruiting PHASE3
Aug 2025 — Sep 2025 [monthly]

Active Not Recruiting PHASE3

Status: Recruiting → Active Not Recruiting
Apr 2025 — Aug 2025 [monthly]

Recruiting PHASE3

▶ Show 8 earlier versions

Mar 2025 — Apr 2025 [monthly]

Recruiting PHASE3
Dec 2024 — Mar 2025 [monthly]

Recruiting PHASE3
Nov 2024 — Dec 2024 [monthly]

Recruiting PHASE3
Oct 2024 — Nov 2024 [monthly]

Recruiting PHASE3
Sep 2024 — Oct 2024 [monthly]

Recruiting PHASE3
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE3
Jun 2024 — Jul 2024 [monthly]

Recruiting PHASE3
May 2024 — Jun 2024 [monthly]

Recruiting PHASE3

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Arrowhead Pharmaceuticals

Data source: Arrowhead Pharmaceuticals

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

A Coruña, Spain , Annapolis, United States , Asheboro, United States , Baltimore, United States , Banská Bystrica, Slovakia , Barcelona, Spain , Bardejov, Slovakia , Beavercreek, United States , Beverly Hills, United States , Birmingham, United States and 172 more locations