deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT06400225

Testing BVD-523FB (Ulixertinib) as Potentially Targeted Treatment in Cancers With Genetic Changes (MATCH - Subprotocol Z1L)

MATCH Treatment Subprotocol Z1L: BVD-523FB (Ulixertinib) in Patients With Tumors With BRAF Fusions, or With Non-V600E, Non-V600K BRAF Mutations

Sponsor: National Cancer Institute (NCI)

Updated 9 times since 2024 Last updated: Nov 1, 2025 Started: Jul 24, 2019 Primary completion: Dec 31, 2026 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Advanced Lymphoma and Advanced Malignant Solid Neoplasm, this trial is ongoing. The trial is conducted by National Cancer Institute (NCI) and has accumulated 9 data snapshots since 2019. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshotActive Not Recruiting~Dec 2024 – ~Mar 2025 · 3 months · monthly snapshotActive Not Recruiting~Mar 2025 – ~May 2025 · 2 months · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Oct 2025 · 4 months · monthly snapshotActive Not Recruiting~Oct 2025 – ~Dec 2025 · 2 months · monthly snapshot~Dec 2025 – present · 8 months · monthly snapshotActive Not Recruiting

Change History

9 versions recorded
  1. Dec 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Oct 2025 — Dec 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Jun 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  4. May 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Mar 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE2

Show 4 earlier versions
  1. Dec 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  4. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

    First recorded

Jul 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations