A Study of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and Long-term Extension Treatment With Aticaprant (VENTURA-7)
A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and an Open Label Long-term Extension Treatment With Aticaprant
Sponsor: Janssen Research & Development, LLC
Terminated
Early study termination due to insufficient efficacy.
Other terminated trials from Janssen Research & Development, LLC
- Multiple Myeloma · Phase PHASE2 · Oct 2025
- Depressive Disorder, Major · May 2025
- Anhedonia · Phase PHASE3 · Apr 2025
- Dengue · Phase PHASE2 · Jun 2024
- Giant Cell Arteritis · Phase PHASE2 · May 2024
More terminations from Janssen Research & Development, LLC
Other Anhedonia trials with similar outcome
Listed as NCT06514742, this PHASE3 trial focuses on Anhedonia and Depressive Disorder, Major and remains terminated or withdrawn. Sponsored by Janssen Research & Development, LLC, it has been updated 14 times since 2024, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
14 versions recorded-
Feb 2026 — Present [monthly]
Terminated PHASE3
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Nov 2025 — Feb 2026 [monthly]
Terminated PHASE3
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Sep 2025 — Nov 2025 [monthly]
Terminated PHASE3
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Aug 2025 — Sep 2025 [monthly]
Terminated PHASE3
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Jul 2025 — Aug 2025 [monthly]
Terminated PHASE3
Status: Active Not Recruiting → Terminated
▶ Show 9 earlier versions
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May 2025 — Jul 2025 [monthly]
Active Not Recruiting PHASE3
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Apr 2025 — May 2025 [monthly]
Active Not Recruiting PHASE3
Status: Recruiting → Active Not Recruiting
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Mar 2025 — Apr 2025 [monthly]
Recruiting PHASE3
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Feb 2025 — Mar 2025 [monthly]
Recruiting PHASE3
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Jan 2025 — Feb 2025 [monthly]
Recruiting PHASE3
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Nov 2024 — Jan 2025 [monthly]
Recruiting PHASE3
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Oct 2024 — Nov 2024 [monthly]
Recruiting PHASE3
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Sep 2024 — Oct 2024 [monthly]
Recruiting PHASE3
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Aug 2024 — Sep 2024 [monthly]
Recruiting PHASE3
First recorded
Jun 2024
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Janssen Research & Development, LLC
For direct contact, visit the study record on ClinicalTrials.gov .