deltatrials
Terminated PHASE3 INTERVENTIONAL 2-arm NCT06514742

A Study of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and Long-term Extension Treatment With Aticaprant (VENTURA-7)

A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy and an Open Label Long-term Extension Treatment With Aticaprant

Sponsor: Janssen Research & Development, LLC

Updated 14 times since 2024 Last updated: Feb 12, 2026 Started: Jun 26, 2024 Primary completion: Apr 8, 2025 Completion: Apr 24, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Early study termination due to insufficient efficacy.

Listed as NCT06514742, this PHASE3 trial focuses on Anhedonia and Depressive Disorder, Major and remains terminated or withdrawn. Sponsored by Janssen Research & Development, LLC, it has been updated 14 times since 2024, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshotRecruiting~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jul 2025 · 2 months · monthly snapshotActive Not Recruiting~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshotTerminated~Nov 2025 – ~Feb 2026 · 3 months · monthly snapshotTerminated~Feb 2026 – present · 6 months · monthly snapshotTerminated

Change History

14 versions recorded
  1. Feb 2026 — Present [monthly]

    Terminated PHASE3

  2. Nov 2025 — Feb 2026 [monthly]

    Terminated PHASE3

  3. Sep 2025 — Nov 2025 [monthly]

    Terminated PHASE3

  4. Aug 2025 — Sep 2025 [monthly]

    Terminated PHASE3

  5. Jul 2025 — Aug 2025 [monthly]

    Terminated PHASE3

    Status: Active Not RecruitingTerminated

Show 9 earlier versions
  1. May 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  3. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE3

  4. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE3

  5. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE3

  6. Nov 2024 — Jan 2025 [monthly]

    Recruiting PHASE3

  7. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE3

  8. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE3

  9. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

    First recorded

Jun 2024

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
Data source: Janssen Research & Development, LLC

For direct contact, visit the study record on ClinicalTrials.gov .