deltatrials
Terminated PHASE2 INTERVENTIONAL 1-arm NCT03758417

A Study of LCAR-B38M CAR-T Cells, a Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Chinese Participants With Relapsed or Refractory Multiple Myeloma (CARTIFAN-1)

A Phase 2, Open-Label Study of LCAR-B38M CAR-T Cells, a Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against BCMA in Chinese Subjects With Relapsed or Refractory Multiple Myeloma

Sponsor: Janssen Research & Development, LLC

Conditions Multiple Myeloma
Interventions LCAR-B38M CAR-T Cell
Updated 22 times since 2018 Last updated: Dec 12, 2025 Started: Jan 23, 2019 Primary completion: Jul 10, 2025 Completion: Oct 20, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The study was terminated early due to a strategic realignment of the sponsor's business plan, not related to safety, efficacy, or data integrity concerns.

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Listed as NCT03758417, this PHASE2 trial focuses on Multiple Myeloma and remains terminated or withdrawn. Sponsored by Janssen Research & Development, LLC, it has been updated 22 times since 2019, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Dec 2018 – ~Apr 2019 · 4 months · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Jan 2020 · 3 months · monthly snapshot~Jan 2020 – ~Sep 2020 · 8 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Feb 2023 · 12 months · monthly snapshot~Feb 2023 – ~Jul 2024 · 17 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Jan 2026 · 3 months · monthly snapshot~Jan 2026 – present · 7 months · monthly snapshot

Change History

22 versions recorded

  1. Jan 2026 — Present [monthly]

    Terminated PHASE2

    Status: Active Not Recruiting → Terminated

  2. Oct 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  5. Sep 2024 — Jul 2025 [monthly]

    Recruiting PHASE2

▶ Show 17 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE2

  2. Feb 2023 — Jul 2024 [monthly]

    Recruiting PHASE2

  3. Feb 2022 — Feb 2023 [monthly]

    Recruiting PHASE2

  4. Dec 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  5. Oct 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE2

  6. Jan 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE2

  7. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  8. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  9. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  10. Jan 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  11. Oct 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  12. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  13. Jul 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  14. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  15. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  16. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  17. Dec 2018 — Apr 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Janssen Research & Development, LLC
  • Nanjing Legend Biotech Co.
Data source: Nanjing Legend Biotech Co.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations