Study of Lunsekimig (SAR443765) Compared With Placebo in Adults With High-risk Asthma (AIRLYMPUS)
A Randomized, Phase 2, Double-blind, Placebo-controlled, Parallel-group, 2-arm Study to Investigate the Efficacy, Safety, and Tolerability of Subcutaneous Lunsekimig (SAR443765) in Adult Participants With High-risk Asthma Who Are Not Currently Eligible for Biologic Treatment
Sponsor: Sanofi
Listed as NCT06676319, this observational or N/A phase trial focuses on Asthma and remains actively recruiting participants. Sponsored by Sanofi, it has been updated 15 times since 2024, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
15 versions recorded-
Apr 17, 2026 — Present [daily]
Recruiting
Phase: PHASE2 → None
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Feb 2026 — Apr 2026 [monthly]
Recruiting PHASE2
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Jan 2026 — Feb 2026 [monthly]
Recruiting PHASE2
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Dec 2025 — Jan 2026 [monthly]
Recruiting PHASE2
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Nov 2025 — Dec 2025 [monthly]
Recruiting PHASE2
▶ Show 10 earlier versions
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Oct 2025 — Nov 2025 [monthly]
Recruiting PHASE2
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Sep 2025 — Oct 2025 [monthly]
Recruiting PHASE2
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Aug 2025 — Sep 2025 [monthly]
Recruiting PHASE2
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Jun 2025 — Aug 2025 [monthly]
Recruiting PHASE2
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May 2025 — Jun 2025 [monthly]
Recruiting PHASE2
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Apr 2025 — May 2025 [monthly]
Recruiting PHASE2
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Mar 2025 — Apr 2025 [monthly]
Recruiting PHASE2
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Feb 2025 — Mar 2025 [monthly]
Recruiting PHASE2
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Jan 2025 — Feb 2025 [monthly]
Recruiting PHASE2
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Dec 2024 — Jan 2025 [monthly]
Recruiting PHASE2
First recorded
Nov 2024
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
This is a parallel-group, Phase 2, randomized, double-blind, placebo-controlled, 2-arm study for the treatment of asthma. The purpose of this study is to assess the efficacy, safety, and tolerability of add-on therapy with subcutaneous (SC) lunsekimig compared with placebo in male and female participants (aged 18 to 80 years, inclusive) with asthma, who are not currently eligible for biologic treatments. Study details include: * The study duration will be approximately 64 weeks for participants not transitioning into the LTS study and approximately 60 weeks for participants transitioning into the LTS study. * The investigational treatment duration will be up to approximately 52 weeks. * The number of visits will be 18.
Contact Information
- Sanofi
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Ahrensburg, Germany , Ajax, Canada , Amiens, France , Ann Arbor, United States , Austin, United States , Badalona, Spain , Barcelona, Spain , Barcelona, Spain , Barnsley, United Kingdom , Beijing, China and 226 more locations