deltatrials
Recruiting PHASE1 INTERVENTIONAL 1-arm NCT06680232

Phase 1 Study to Evaluate Safety and Antiviral Activity of PBGENE-HBV in Adult Patients With Chronic Hepatitis B (ELIMINATE-B)

A Phase 1, Open-Label, First-in-Human, Dose Escalation (Part 1) and Expansion (Part 2) Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antiviral Activity of PBGENE-HBV in Participants With Chronic Hepatitis B (ELIMINATE-B)

Sponsor: Precision BioSciences, Inc.

Conditions HEPATITIS B CHRONIC
Interventions PBGENE-HBV
Updated 5 times since 2024 Last updated: Sep 22, 2025 Started: Nov 14, 2024 Primary completion: Dec 31, 2025 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates HEPATITIS B CHRONIC and is currently actively recruiting participants. Precision BioSciences, Inc. leads this study, which shows 5 recorded versions since 2024 — indicating limited longitudinal coverage. Longitudinal tracking of infectious disease trials helps identify durability of treatment effects.

Status Flow

~Dec 2024 – ~Feb 2025 · 2 months · monthly snapshotRecruiting~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Sep 2025 · 6 months · monthly snapshotRecruiting~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – present · 9 months · monthly snapshotRecruiting

Change History

5 versions recorded

  1. Oct 2025 — Present [monthly]

    Recruiting PHASE1

  2. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE1

  3. Mar 2025 — Sep 2025 [monthly]

    Recruiting PHASE1

  4. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE1

  5. Dec 2024 — Feb 2025 [monthly]

    Recruiting PHASE1

    First recorded

Nov 2024

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Precision BioSciences, Inc.
Data source: Precision BioSciences, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations