Recruiting OBSERVATIONAL NCT06696027

AYLo - AutoimmunitY and Loss of y (AYLo)

Investigating the Role of Hematopoietic Mutations and Mosaic Mutation in the Y Chromosome in Autoimmune Rheumatologic Diseases

Sponsor: University of Bonn

Conditions ANCA Associated Vasculitis (AAV) Asthma Bronchiale COPD Connective Tissue Disease Giant Cell Arteritis (GCA) Idiopathic Inflammatory Myopathies IgG4-Related Diseases Interstitial Lung Disease (ILD) Interstitial Lung Disease Due to Systemic Disease (Disorder) Polymyalgia Rheumatica (PMR) Psoriatic Arthritis (PsA) Rheumatoid Arthritis (RA) Sarcoidosis

Interventions 3'mRNA sequencing Assessment of Pulmonary Involvement Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array Flow Cytometry Laboratory assessment Single nucleotide polymorphisms (SNP)

Updated 3 times since 2024 Last updated: Apr 7, 2025 Started: Nov 15, 2024 Primary completion: Dec 31, 2025 Completion: Jul 31, 2026

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This observational or N/A phase trial investigates ANCA Associated Vasculitis (AAV) and Asthma Bronchiale and is currently actively recruiting participants. University of Bonn leads this study, which shows 3 recorded versions since 2024 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

3 versions recorded

May 2025 — Present [monthly]

Recruiting
Feb 2025 — May 2025 [monthly]

Recruiting

Status: Not Yet Recruiting → Recruiting
Dec 2024 — Feb 2025 [monthly]

Not Yet Recruiting

First recorded

Nov 2024

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

University of Bonn

Data source: University of Bonn

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Bonn, Germany