Recruiting PHASE4 INTERVENTIONAL 2-arm NCT06731374

Carriage to Assess Protection of New Pneumococcal Vaccines - PCV15 (RATIONALE-15)

A Phase IV, Experimental Human Pneumococcal Challenge (EHPC) Model to Investigate Streptococcus Pneumoniae Serotype 3 (SPN3) Colonisation Following PCV15, a Double Blind Randomised Controlled Trial (DBRCT) in Healthy Participants Aged 18 - 50 Years in the UK.

Sponsor: Liverpool School of Tropical Medicine, United Kingdom

Conditions Pneumococcal Carriage Pneumococcal Disease

Interventions PCV15 Placebo Streptococcus pneumoniae serotype 3

Updated 3 times since 2025 Last updated: Apr 11, 2025 Started: Feb 24, 2025 Primary completion: Dec 31, 2025 Completion: Dec 31, 2026

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE4 clinical study on Pneumococcal Carriage and Pneumococcal Disease, this trial is actively recruiting participants. The trial is conducted by Liverpool School of Tropical Medicine, United Kingdom and has accumulated 3 data snapshots since 2025. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

3 versions recorded

May 2025 — Present [monthly]

Recruiting PHASE4
Apr 2025 — May 2025 [monthly]

Recruiting PHASE4

Status: Not Yet Recruiting → Recruiting
Jan 2025 — Apr 2025 [monthly]

Not Yet Recruiting PHASE4

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Liverpool School of Tropical Medicine, United Kingdom
Oxford University Hospitals NHS Trust
University of Oxford

Data source: University of Oxford

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Liverpool, United Kingdom
• Oxford, United Kingdom