Completed PHASE1 INTERVENTIONAL 1-arm NCT00069459

Seasonal Affective Depression (SAD) Study

A 7 Month, Multicenter, Parallel, Double-Blind, Placebo-Controlled Comparison of 150-300 mg/Day of Extended-Release Bupropion Hydrochloride and Placebo for the Prevention of Seasonal Depressive Episodes in Subjects With a History of Seasonal Affective Disorder Followed by an 8-week Observational Follow-up Phase

Sponsor: GlaxoSmithKline

Conditions Depressive Disorder

Interventions Extended-release Bupropion Hydrochloride

Updated 8 times since 2017 Last updated: Sep 21, 2017 Started: Sep 23, 2003 Primary completion: Jun 3, 2004 Completion: Jun 3, 2004

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Depressive Disorder and is currently completed. GlaxoSmithKline leads this study, which shows 8 recorded versions since 2003 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

8 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE1
Sep 2024 — Sep 2025 [monthly]

Completed PHASE1
Jul 2024 — Sep 2024 [monthly]

Completed PHASE1
Jan 2021 — Jul 2024 [monthly]

Completed PHASE1
Jun 2018 — Jan 2021 [monthly]

Completed PHASE1

▶ Show 3 earlier versions

Oct 2017 — Jun 2018 [monthly]

Completed PHASE1

Phase: PHASE2 → PHASE1
Feb 2017 — Oct 2017 [monthly]

Completed PHASE2
Jan 2017 — Feb 2017 [monthly]

Completed PHASE2

First recorded

Sep 2003

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

GlaxoSmithKline

Data source: GlaxoSmithKline

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albany, United States , Allentown, United States , Anchorage, United States , Baltimore, United States , Belmont, United States , Boise, United States , Brown Deer, United States , Cedar Rapids, United States , Cincinnati, United States , Columbus, United States and 34 more locations