deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT01231906

Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma

A Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-Metastatic Ewing Sarcoma

Sponsor: Children's Oncology Group

Conditions Localized Extraskeletal Ewing Sarcoma Peripheral Primitive Neuroectodermal Tumor of Bone Peripheral Primitive Neuroectodermal Tumor of Soft Tissues
Interventions Cyclophosphamide Dexrazoxane Doxorubicin Hydrochloride Etoposide Ifosfamide Laboratory Biomarker Analysis Topotecan Hydrochloride Vincristine Sulfate
Updated 24 times since 2017 Last updated: Jan 6, 2026 Started: Nov 24, 2010 Primary completion: Mar 31, 2020 Completion: Dec 31, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Localized Extraskeletal Ewing Sarcoma and Peripheral Primitive Neuroectodermal Tumor of Bone, this trial is completed. The trial is conducted by Children's Oncology Group and has accumulated 24 data snapshots since 2010. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2018 · 16 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Apr 2019 · 3 months · monthly snapshot~Apr 2019 – ~Sep 2019 · 5 months · monthly snapshot~Sep 2019 – ~Jan 2020 · 4 months · monthly snapshot~Jan 2020 – ~Apr 2020 · 3 months · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Jun 2021 · 4 months · monthly snapshot~Jun 2021 – ~Jun 2022 · 12 months · monthly snapshot~Jun 2022 – ~Jul 2023 · 13 months · monthly snapshot~Jul 2023 – ~Sep 2023 · 2 months · monthly snapshot~Sep 2023 – ~Jul 2024 · 10 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Sep 2025 · 11 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Feb 2026 · 3 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

24 versions recorded

  1. Feb 2026 — Present [monthly]

    Completed PHASE3

    Status: Unknown → Completed

  2. Nov 2025 — Feb 2026 [monthly]

    Unknown PHASE3

    Status: Active Not Recruiting → Unknown

  3. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Oct 2024 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

▶ Show 19 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  2. Sep 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Jul 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  4. Jun 2022 — Jul 2023 [monthly]

    Active Not Recruiting PHASE3

  5. Jun 2021 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  6. Feb 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

  7. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE3

  8. Sep 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  9. Apr 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  10. Jan 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  11. Sep 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

  12. Apr 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE3

  13. Jan 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE3

  14. Nov 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE3

  15. Sep 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE3

  16. Aug 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE3

  17. Jun 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE3

  18. Feb 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

    Status: Suspended → Active Not Recruiting

  19. Jan 2017 — Feb 2017 [monthly]

    Suspended PHASE3

    First recorded

Nov 2010

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Children's Oncology Group
  • National Cancer Institute (NCI)
Data source: Children's Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Albany, United States , Albuquerque, United States , Anchorage, United States , Ann Arbor, United States , Asheville, United States , Atlanta, United States , Augusta, United States , Aurora, United States , Austin, United States and 164 more locations