deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 2-arm NCT02306161

Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma

Randomized Phase 3 Trial Evaluating the Addition of the IGF-1R Monoclonal Antibody Ganitumab (AMG 479, NSC# 750008) to Multiagent Chemotherapy for Patients With Newly Diagnosed Metastatic Ewing Sarcoma

Sponsor: National Cancer Institute (NCI)

Conditions Metastatic Ewing Sarcoma Metastatic Malignant Neoplasm in the Bone Metastatic Malignant Neoplasm in the Bone Marrow Metastatic Malignant Neoplasm in the Lung Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone Peripheral Primitive Neuroectodermal Tumor of Soft Tissues
Interventions Cyclophosphamide Doxorubicin Doxorubicin Hydrochloride Etoposide Etoposide Phosphate External Beam Radiation Therapy Ganitumab Ifosfamide Stereotactic Radiosurgery Therapeutic Surgical Procedure Vincristine Vincristine Sulfate
Updated 76 times since 2017 Last updated: Mar 12, 2026 Started: Dec 12, 2014 Primary completion: Mar 31, 2021 Completion: Sep 17, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Metastatic Ewing Sarcoma and Metastatic Malignant Neoplasm in the Bone, this trial is ongoing. The trial is conducted by National Cancer Institute (NCI) and has accumulated 76 data snapshots since 2014. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Sep 2017 · 3 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~May 2018 · 3 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Nov 2021 · 6 months · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Sep 2022 · 5 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~May 2023 · 2 months · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Nov 2023 · 5 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jun 2024 · 2 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Jan 2025 · 3 months · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Jun 2025 · 2 months · monthly snapshot~Jun 2025 – ~Aug 2025 · 2 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Jan 2026 · 2 months · monthly snapshot~Jan 2026 – ~Mar 2026 · 59 days · monthly snapshot~Mar 2026 – present · 5 months · monthly snapshot

Change History

76 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Jan 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Nov 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  4. Sep 2025 — Nov 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 71 earlier versions

  1. Jun 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Apr 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Feb 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Jan 2025 — Feb 2025 [monthly]

    Active Not Recruiting PHASE3

  6. Oct 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  7. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE3

  8. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  9. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  10. Apr 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

  11. Mar 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  12. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE3

  13. Dec 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  14. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  15. Jun 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  16. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  17. Mar 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  18. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  19. Jan 2023 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  20. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  21. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  22. Apr 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  23. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  24. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE3

  25. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  26. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE3

  27. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

  28. May 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE3

  29. Apr 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE3

  30. Feb 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE3

  31. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE3

  32. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  33. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  34. Aug 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE3

  35. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  36. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  37. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE3

  38. Apr 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  39. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  40. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE3

  41. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  42. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

  43. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE3

  44. Oct 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  45. Sep 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE3

  46. Aug 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE3

  47. Jul 2019 — Aug 2019 [monthly]

    Active Not Recruiting PHASE3

  48. Jun 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE3

  49. May 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE3

  50. Apr 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  51. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  52. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  53. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  54. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  55. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  56. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  57. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  58. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  59. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  60. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  61. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  62. Feb 2018 — May 2018 [monthly]

    Recruiting PHASE3

  63. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE3

  64. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE3

  65. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  66. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  67. Jun 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  68. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

  69. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE3

  70. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE3

  71. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Dec 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Albany, United States , Allentown, United States , Anchorage, United States , Ann Arbor, United States , Asheville, United States , Atlanta, United States , Augusta, United States , Aurora, United States , Austin, United States and 202 more locations