deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT01271712

Study of Regorafenib as a 3rd-line or Beyond Treatment for Gastrointestinal Stromal Tumors (GIST) (GRID)

A Randomized, Double-blind, Placebo-controlled Phase III Study of Regorafenib Plus Best Supportive Care Versus Placebo Plus Best Supportive Care for Subjects With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors (GIST) Whose Disease Has Progressed Despite Prior Treatment With at Least Imatinib and Sunitinib

Sponsor: Bayer

Updated 24 times since 2017 Last updated: Jan 27, 2021 Started: Jan 4, 2011 Primary completion: Jan 26, 2012 Completion: Apr 15, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Gastrointestinal Stromal Tumors and is currently completed. Bayer leads this study, which shows 24 recorded versions since 2011 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Oct 2017 · 8 months · monthly snapshot~Oct 2017 – ~Mar 2018 · 5 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~May 2020 · 11 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jan 2021 · 7 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Dec 2021 · 10 months · monthly snapshot~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 7 months · monthly snapshot

Change History

24 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Dec 2021 — Jul 2024 [monthly]

    Completed PHASE3

  5. Feb 2021 — Dec 2021 [monthly]

    Completed PHASE3

Show 19 earlier versions
  1. Jan 2021 — Feb 2021 [monthly]

    Completed PHASE3

  2. Jun 2020 — Jan 2021 [monthly]

    Completed PHASE3

  3. May 2020 — Jun 2020 [monthly]

    Completed PHASE3

  4. Jun 2019 — May 2020 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  5. May 2019 — Jun 2019 [monthly]

    Active Not Recruiting PHASE3

  6. Apr 2019 — May 2019 [monthly]

    Active Not Recruiting PHASE3

  7. Mar 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE3

  8. Feb 2019 — Mar 2019 [monthly]

    Active Not Recruiting PHASE3

  9. Jan 2019 — Feb 2019 [monthly]

    Active Not Recruiting PHASE3

  10. Nov 2018 — Jan 2019 [monthly]

    Active Not Recruiting PHASE3

  11. Oct 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE3

  12. Sep 2018 — Oct 2018 [monthly]

    Active Not Recruiting PHASE3

  13. Aug 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE3

  14. Jul 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE3

  15. Jun 2018 — Jul 2018 [monthly]

    Active Not Recruiting PHASE3

  16. Mar 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  17. Oct 2017 — Mar 2018 [monthly]

    Active Not Recruiting PHASE3

  18. Feb 2017 — Oct 2017 [monthly]

    Active Not Recruiting PHASE3

  19. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE3

    First recorded

Jan 2011

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bayer
Data source: Bayer

For direct contact, visit the study record on ClinicalTrials.gov .