Completed PHASE2 INTERVENTIONAL 2-arm NCT01412879

S1106 Rituximab With Combination Chemotherapy or Bendamustine Hydrochloride Followed by Consolidation Chemotherapy and Stem Cell Transplantation in Older Patients With Previously Untreated Mantle Cell Lymphoma

A Randomized Phase II Trial of R-HCVAD/MTX/ARA-C Induction Followed by Consolidation With an Autologous Stem Cell Transplant Vs. R-Bendamustine Induction Followed by Consolidation With an Autologous Stem Cell Transplant for Patients ≤ 65 Years of Age With Previously Untreated Mantle Cell Lymphoma

Sponsor: National Cancer Institute (NCI)

Conditions Lymphoma

Interventions bendamustine hydrochloride cyclophosphamide cytarabine dexamethasone doxorubicin hydrochloride leucovorin calcium methotrexate rituximab vincristine sulfate

Updated 14 times since 2017 Last updated: Oct 14, 2021 Started: Nov 30, 2011 Primary completion: Feb 29, 2016 Completion: Mar 31, 2021

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT01412879, this PHASE2 trial focuses on Lymphoma and remains completed. Sponsored by National Cancer Institute (NCI), it has been updated 14 times since 2011, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

Change History

14 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE2
Sep 2024 — Sep 2025 [monthly]

Completed PHASE2
Jul 2024 — Sep 2024 [monthly]

Completed PHASE2
May 2023 — Jul 2024 [monthly]

Completed PHASE2
Nov 2021 — May 2023 [monthly]

Completed PHASE2

Status: Active Not Recruiting → Completed

▶ Show 9 earlier versions

Jun 2021 — Nov 2021 [monthly]

Active Not Recruiting PHASE2
Jan 2021 — Jun 2021 [monthly]

Active Not Recruiting PHASE2
May 2020 — Jan 2021 [monthly]

Active Not Recruiting PHASE2
May 2019 — May 2020 [monthly]

Active Not Recruiting PHASE2
Jun 2018 — May 2019 [monthly]

Active Not Recruiting PHASE2
Mar 2018 — Jun 2018 [monthly]

Active Not Recruiting PHASE2

Status: Terminated → Active Not Recruiting
Jul 2017 — Mar 2018 [monthly]

Terminated PHASE2
Feb 2017 — Jul 2017 [monthly]

Terminated PHASE2
Jan 2017 — Feb 2017 [monthly]

Terminated PHASE2

First recorded

Nov 2011

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

National Cancer Institute (NCI)
SWOG Cancer Research Network

Data source: SWOG Cancer Research Network

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Adrian, United States , Ames, United States , Anacortes, United States , Aurora, United States , Beech Grove, United States , Bellevue, United States , Bellingham, United States , Bloomington, United States , Boulder, United States , Bremerton, United States and 134 more locations