Transcranial Doppler (TCD) With Transfusions Changing to Hydroxyurea (TWiTCH)
TCD With Transfusions Changing to Hydroxyurea (TWiTCH): A Phase III Randomized Trial to Compare Standard Therapy (Erythrocyte Transfusions) With Alternative Therapy (Hydroxyurea) for the Maintenance of Lowered TCD Velocities in Pediatric Subjects With Sickle Cell Anemia and Abnormal Pre-treatment TCD Velocities
Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago
Terminated
The study was stopped early due to successfully meeting the primary endpoint
Other terminated trials from Ann & Robert H Lurie Children's Hospital of Chicago
- Heart Defects, Congenital · Oct 2025
- Anaplastic Ependymoma · Phase PHASE1 · Nov 2019
- Diffuse Intrinsic Pontine Glioma · Phase PHASE2 · Jun 2016
- Fatigue · Phase PHASE2 · Dec 2015
- Ependymoma · Phase PHASE2 · Apr 2015
See all terminations from Ann & Robert H Lurie Children's Hospital of Chicago
Other Sickle Cell Anemia trials with similar outcome
A PHASE3 clinical study on Sickle Cell Anemia, this trial is terminated or withdrawn. The trial is conducted by Ann & Robert H Lurie Children's Hospital of Chicago and has accumulated 14 data snapshots since 2011. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.
Status Flow
Change History
14 versions recorded-
Sep 2024 — Present [monthly]
Terminated PHASE3
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Jul 2024 — Sep 2024 [monthly]
Terminated PHASE3
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Jan 2023 — Jul 2024 [monthly]
Terminated PHASE3
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Dec 2022 — Jan 2023 [monthly]
Terminated PHASE3
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Dec 2021 — Dec 2022 [monthly]
Terminated PHASE3
▶ Show 9 earlier versions
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Jan 2021 — Dec 2021 [monthly]
Terminated PHASE3
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Sep 2020 — Jan 2021 [monthly]
Terminated PHASE3
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Aug 2020 — Sep 2020 [monthly]
Terminated PHASE3
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Mar 2020 — Aug 2020 [monthly]
Terminated PHASE3
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Feb 2020 — Mar 2020 [monthly]
Terminated PHASE3
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Jun 2018 — Feb 2020 [monthly]
Terminated PHASE3
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May 2017 — Jun 2018 [monthly]
Terminated PHASE3
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Feb 2017 — May 2017 [monthly]
Terminated PHASE3
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Jan 2017 — Feb 2017 [monthly]
Terminated PHASE3
First recorded
Aug 2011
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Ann & Robert H Lurie Children's Hospital of Chicago
- Baylor College of Medicine
- Boston Children's Hospital
- Children's Healthcare of Atlanta
- Children's Hospital Medical Center, Cincinnati
- Children's Hospital of Philadelphia
- Children's Hospital of The King's Daughters
- Children's Hospitals and Clinics of Minnesota
- Children's National Research Institute
- Columbia University
- Duke University
- East Carolina University
- Medical University of South Carolina
- National Heart, Lung, and Blood Institute (NHLBI)
- Nemours Children's Clinic
- St. Jude Children's Research Hospital
- State University of New York - Downstate Medical Center
- Steven and Alexandra Cohen Children's Medical Center
- The Hospital for Sick Children
- University Hospitals Cleveland Medical Center
- University of Alabama at Birmingham
- University of Miami
- University of Mississippi Medical Center
- University of South Alabama
- University of Texas Southwestern Medical Center
- Wayne State University
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
No location information available.