Terminated PHASE1 INTERVENTIONAL 2-arm NCT02722512

Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine

A Phase I and Feasibility Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine for Pediatric Patients With Newly Diagnosed Intracranial High Grade Glioma and Recurrent Resectable Intracranial High Grade Glioma and Ependymoma

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Conditions Anaplastic Ependymoma Astrocytoma, Grade III Clear Cell Ependymoma Ependymoma Glioblastoma Multiforme

Interventions Heat Shock Protein Peptide Complex-96 (HSPPC-96) Radiation Tumor Resection

Updated 9 times since 2017 Last updated: Feb 14, 2025 Started: Jul 31, 2016 Primary completion: Nov 13, 2019 Completion: Nov 13, 2019

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Lack of substantial evidence for immune responses in response to vaccination.

Other terminated trials from Ann & Robert H Lurie Children's Hospital of Chicago

See all terminations from Ann & Robert H Lurie Children's Hospital of Chicago

Other Anaplastic Ependymoma trials with similar outcome

NCT03727841 · Phase PHASE2 · Apr 2021

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This PHASE1 trial investigates Anaplastic Ependymoma and Astrocytoma, Grade III and is currently terminated or withdrawn. Ann & Robert H Lurie Children's Hospital of Chicago leads this study, which shows 9 recorded versions since 2016 — indicating limited longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

Change History

9 versions recorded

Mar 2025 — Present [monthly]

Terminated PHASE1
Sep 2024 — Mar 2025 [monthly]

Terminated PHASE1
Jul 2024 — Sep 2024 [monthly]

Terminated PHASE1
Jan 2021 — Jul 2024 [monthly]

Terminated PHASE1
Aug 2020 — Jan 2021 [monthly]

Terminated PHASE1

Status: Recruiting → Terminated

▶ Show 4 earlier versions

Mar 2019 — Aug 2020 [monthly]

Recruiting PHASE1
Jun 2018 — Mar 2019 [monthly]

Recruiting PHASE1
Feb 2017 — Jun 2018 [monthly]

Recruiting PHASE1
Jan 2017 — Feb 2017 [monthly]

Recruiting PHASE1

First recorded

Jul 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Ann & Robert H Lurie Children's Hospital of Chicago
Northwestern University

Data source: Ann & Robert H Lurie Children's Hospital of Chicago

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

• Chicago, United States