deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 1-arm NCT01591356

EphA2 siRNA in Treating Patients With Advanced or Recurrent Solid Tumors

EphA2 Gene Targeting Using Neutral Liposomal Small Interfering RNA Delivery: A Phase I Clinical Trial

Sponsor: Gateway for Cancer Research

Conditions Advanced Malignant Solid Neoplasm
Interventions EphA2-targeting DOPC-encapsulated siRNA Laboratory Biomarker Analysis Pharmacological Study
Updated 26 times since 2017 Last updated: Jan 5, 2026 Started: Jul 1, 2015 Primary completion: Apr 30, 2027 Completion: Apr 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Advanced Malignant Solid Neoplasm and is currently ongoing. Gateway for Cancer Research leads this study, which shows 26 recorded versions since 2015 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jul 2017 · 5 months · monthly snapshot~Jul 2017 – ~Jun 2018 · 11 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Nov 2018 · 4 months · monthly snapshot~Nov 2018 – ~Feb 2019 · 3 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Jun 2019 · 3 months · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Jan 2021 · 14 months · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Mar 2022 · 10 months · monthly snapshot~Mar 2022 – ~Jul 2022 · 4 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Mar 2023 · 6 months · monthly snapshot~Mar 2023 – ~Jul 2023 · 4 months · monthly snapshot~Jul 2023 – ~Oct 2023 · 3 months · monthly snapshot~Oct 2023 – ~Apr 2024 · 6 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Aug 2025 · 6 months · monthly snapshot~Aug 2025 – ~Feb 2026 · 6 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

26 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Aug 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Feb 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

▶ Show 21 earlier versions

  1. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  2. Oct 2023 — Apr 2024 [monthly]

    Recruiting PHASE1

  3. Jul 2023 — Oct 2023 [monthly]

    Recruiting PHASE1

  4. Mar 2023 — Jul 2023 [monthly]

    Recruiting PHASE1

  5. Sep 2022 — Mar 2023 [monthly]

    Recruiting PHASE1

    Status: Active Not Recruiting → Recruiting

  6. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  7. Mar 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

  8. May 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  9. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE1

  10. Nov 2019 — Jan 2021 [monthly]

    Recruiting PHASE1

  11. Sep 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  12. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  13. Jun 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  14. Mar 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  15. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  16. Nov 2018 — Feb 2019 [monthly]

    Recruiting PHASE1

  17. Jul 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  18. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

  19. Jul 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

  20. Feb 2017 — Jul 2017 [monthly]

    Recruiting PHASE1

  21. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1

    First recorded

Jul 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Gateway for Cancer Research
  • Institutional Funding for Federally Supported Clinical Trials (IFSCT)
  • M.D. Anderson Cancer Center
  • National Cancer Institute (NCI)
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations