Trametinib in Treating Patients With Advanced Cancer With or Without Hepatic Dysfunction
A Phase I Trial of Single Agent Trametinib (GSK1120212) in Advanced Cancer Patients With Hepatic Dysfunction
Sponsor: National Cancer Institute (NCI)
This PHASE1 trial investigates Advanced Malignant Solid Neoplasm and Metastatic Malignant Neoplasm in the Liver and is currently completed. National Cancer Institute (NCI) leads this study, which shows 44 recorded versions since 2014 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.
Status Flow
Change History
44 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE1
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Mar 2025 — Sep 2025 [monthly]
Completed PHASE1
Status: Active Not Recruiting → Completed
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Jan 2025 — Mar 2025 [monthly]
Active Not Recruiting PHASE1
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Dec 2024 — Jan 2025 [monthly]
Active Not Recruiting PHASE1
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Nov 2024 — Dec 2024 [monthly]
Active Not Recruiting PHASE1
▶ Show 39 earlier versions
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Sep 2024 — Nov 2024 [monthly]
Active Not Recruiting PHASE1
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Aug 2024 — Sep 2024 [monthly]
Active Not Recruiting PHASE1
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Jul 2024 — Aug 2024 [monthly]
Active Not Recruiting PHASE1
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Jun 2024 — Jul 2024 [monthly]
Active Not Recruiting PHASE1
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Dec 2023 — Jun 2024 [monthly]
Active Not Recruiting PHASE1
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Apr 2023 — Dec 2023 [monthly]
Active Not Recruiting PHASE1
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Sep 2022 — Apr 2023 [monthly]
Active Not Recruiting PHASE1
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Jul 2022 — Sep 2022 [monthly]
Active Not Recruiting PHASE1
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Mar 2022 — Jul 2022 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
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Oct 2021 — Mar 2022 [monthly]
Recruiting PHASE1
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Sep 2021 — Oct 2021 [monthly]
Recruiting PHASE1
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Apr 2021 — Sep 2021 [monthly]
Recruiting PHASE1
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Mar 2021 — Apr 2021 [monthly]
Recruiting PHASE1
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Jan 2021 — Mar 2021 [monthly]
Recruiting PHASE1
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Sep 2020 — Jan 2021 [monthly]
Recruiting PHASE1
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Aug 2020 — Sep 2020 [monthly]
Recruiting PHASE1
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Jul 2020 — Aug 2020 [monthly]
Recruiting PHASE1
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Apr 2020 — Jul 2020 [monthly]
Recruiting PHASE1
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Mar 2020 — Apr 2020 [monthly]
Recruiting PHASE1
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Feb 2020 — Mar 2020 [monthly]
Recruiting PHASE1
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Nov 2019 — Feb 2020 [monthly]
Recruiting PHASE1
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Oct 2019 — Nov 2019 [monthly]
Recruiting PHASE1
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Sep 2019 — Oct 2019 [monthly]
Recruiting PHASE1
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May 2019 — Sep 2019 [monthly]
Recruiting PHASE1
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Apr 2019 — May 2019 [monthly]
Recruiting PHASE1
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Mar 2019 — Apr 2019 [monthly]
Recruiting PHASE1
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Jan 2019 — Mar 2019 [monthly]
Recruiting PHASE1
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Dec 2018 — Jan 2019 [monthly]
Recruiting PHASE1
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Oct 2018 — Dec 2018 [monthly]
Recruiting PHASE1
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Sep 2018 — Oct 2018 [monthly]
Recruiting PHASE1
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Aug 2018 — Sep 2018 [monthly]
Recruiting PHASE1
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Jun 2018 — Aug 2018 [monthly]
Recruiting PHASE1
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May 2018 — Jun 2018 [monthly]
Recruiting PHASE1
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Mar 2018 — May 2018 [monthly]
Recruiting PHASE1
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Nov 2017 — Mar 2018 [monthly]
Recruiting PHASE1
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Jun 2017 — Nov 2017 [monthly]
Recruiting PHASE1
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May 2017 — Jun 2017 [monthly]
Recruiting PHASE1
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Feb 2017 — May 2017 [monthly]
Recruiting PHASE1
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Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE1
First recorded
Mar 2014
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- National Cancer Institute (NCI)
For direct contact, visit the study record on ClinicalTrials.gov .