deltatrials
Completed PHASE1 INTERVENTIONAL 2-arm NCT01628640

Viral Therapy in Treating Patient With Refractory Liver Cancer or Advanced Solid Tumors

Phase I Trial of Intratumoral Injection of Vesicular Stomatitis Virus Expressing Human Interferon Beta in Patients With Sorafenib Refractory/Intolerant Hepatocellular Carcinoma, Advanced Solid Tumors With Liver Predominant Locally Advanced/Metastatic Disease or Subcutaneous/Cutaneous Lesions

Sponsor: Mayo Clinic

Conditions Advanced Malignant Solid Neoplasm Hepatocellular Carcinoma
Interventions Laboratory Biomarker Analysis Pharmacological Study Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta
Updated 17 times since 2017 Last updated: Jul 1, 2025 Started: Aug 3, 2012 Primary completion: Apr 19, 2019 Completion: Apr 19, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Advanced Malignant Solid Neoplasm and Hepatocellular Carcinoma and is currently completed. Mayo Clinic leads this study, which shows 17 recorded versions since 2012 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jul 2017 · 5 months · monthly snapshot~Jul 2017 – ~Oct 2017 · 3 months · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~May 2019 · 9 months · monthly snapshot~May 2019 – ~Jun 2020 · 13 months · monthly snapshot~Jun 2020 – ~Oct 2020 · 4 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Nov 2021 · 10 months · monthly snapshot~Nov 2021 – ~Nov 2022 · 12 months · monthly snapshot~Nov 2022 – ~Aug 2023 · 9 months · monthly snapshot~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Aug 2025 · 6 months · monthly snapshot~Aug 2025 – present · 13 months · monthly snapshot

Change History

17 versions recorded

  1. Aug 2025 — Present [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  2. Feb 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Aug 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 12 earlier versions

  1. Nov 2022 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  2. Nov 2021 — Nov 2022 [monthly]

    Active Not Recruiting PHASE1

  3. Jan 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE1

  4. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  5. Jun 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE1

  6. May 2019 — Jun 2020 [monthly]

    Active Not Recruiting PHASE1

    Status: Suspended → Active Not Recruiting

  7. Aug 2018 — May 2019 [monthly]

    Suspended PHASE1

  8. Jun 2018 — Aug 2018 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  9. Oct 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  10. Jul 2017 — Oct 2017 [monthly]

    Suspended PHASE1

  11. Feb 2017 — Jul 2017 [monthly]

    Suspended PHASE1

  12. Jan 2017 — Feb 2017 [monthly]

    Suspended PHASE1

    First recorded

Aug 2012

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Mayo Clinic
  • National Cancer Institute (NCI)
Data source: Mayo Clinic

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations