deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 3-arm NCT02114229

Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors (SJATRT)

Phase 2 Study of Alisertib as a Single Agent in Recurrent or Progressive Central Nervous System (CNS) Atypical Teratoid Rhabdoid Tumors (AT/RT) and Extra-CNS Malignant Rhabdoid Tumors (MRT) and in Combination Therapy in Newly Diagnosed AT/RT

Sponsor: Millennium Pharmaceuticals, Inc.

Conditions Atypical Teratoid Rhabdoid Tumor Malignant Rhabdoid Tumor
Interventions Radiation therapy Surgical resection alisertib carboplatin cisplatin cyclophosphamide etoposide methotrexate topotecan vincristine
Updated 25 times since 2017 Last updated: Apr 8, 2025 Started: May 14, 2014 Primary completion: Sep 30, 2025 Completion: Sep 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Atypical Teratoid Rhabdoid Tumor and Malignant Rhabdoid Tumor and is currently ongoing. Millennium Pharmaceuticals, Inc. leads this study, which shows 25 recorded versions since 2014 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Aug 2017 · 2 months · monthly snapshot~Aug 2017 – ~Mar 2018 · 7 months · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jan 2019 · 7 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Feb 2020 · 12 months · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Apr 2022 · 7 months · monthly snapshot~Apr 2022 – ~Sep 2022 · 5 months · monthly snapshot~Sep 2022 – ~Apr 2023 · 7 months · monthly snapshot~Apr 2023 – ~Aug 2023 · 4 months · monthly snapshot~Aug 2023 – ~Nov 2023 · 3 months · monthly snapshot~Nov 2023 – ~Mar 2024 · 4 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~May 2025 · 6 months · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

25 versions recorded

  1. Sep 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. May 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Nov 2024 — May 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 20 earlier versions

  1. Mar 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Nov 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Aug 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE2

  4. Apr 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  5. Sep 2022 — Apr 2023 [monthly]

    Recruiting PHASE2

  6. Apr 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  7. Sep 2021 — Apr 2022 [monthly]

    Recruiting PHASE2

  8. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  9. Jul 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  10. May 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  11. Feb 2020 — May 2020 [monthly]

    Recruiting PHASE2

  12. Feb 2019 — Feb 2020 [monthly]

    Recruiting PHASE2

  13. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  14. Jun 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  15. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  16. Aug 2017 — Mar 2018 [monthly]

    Recruiting PHASE2

  17. Jun 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  18. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE2

  19. Feb 2017 — May 2017 [monthly]

    Recruiting PHASE2

  20. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE2

    First recorded

May 2014

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Millennium Pharmaceuticals, Inc.
  • St. Jude Children's Research Hospital
  • Takeda Pharmaceuticals U.S.A., Inc.
Data source: St. Jude Children's Research Hospital

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations