Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas
A Phase 1 Study of Selinexor (KPT-330), A Selective XPO1 Inhibitor, in Recurrent and Refractory Pediatric Solid Tumors, Including CNS Tumors
Sponsor: Children's Oncology Group
Listed as NCT02323880, this PHASE1 trial focuses on Malignant Glioma and Recurrent Brain Neoplasm and remains completed. Sponsored by Children's Oncology Group, it has been updated 28 times since 2015, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.
Status Flow
Change History
28 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE1
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Feb 2025 — Sep 2025 [monthly]
Completed PHASE1
Status: Active Not Recruiting → Completed
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Dec 2024 — Feb 2025 [monthly]
Active Not Recruiting PHASE1
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Sep 2024 — Dec 2024 [monthly]
Active Not Recruiting PHASE1
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Jul 2024 — Sep 2024 [monthly]
Active Not Recruiting PHASE1
▶ Show 23 earlier versions
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Feb 2024 — Jul 2024 [monthly]
Active Not Recruiting PHASE1
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Nov 2023 — Feb 2024 [monthly]
Active Not Recruiting PHASE1
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Nov 2022 — Nov 2023 [monthly]
Active Not Recruiting PHASE1
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Sep 2022 — Nov 2022 [monthly]
Active Not Recruiting PHASE1
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Jul 2022 — Sep 2022 [monthly]
Active Not Recruiting PHASE1
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May 2022 — Jul 2022 [monthly]
Active Not Recruiting PHASE1
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Mar 2022 — May 2022 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
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Sep 2021 — Mar 2022 [monthly]
Recruiting PHASE1
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Jun 2021 — Sep 2021 [monthly]
Recruiting PHASE1
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May 2021 — Jun 2021 [monthly]
Recruiting PHASE1
-
Mar 2021 — May 2021 [monthly]
Recruiting PHASE1
Status: Active Not Recruiting → Recruiting
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Jan 2021 — Mar 2021 [monthly]
Active Not Recruiting PHASE1
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Sep 2020 — Jan 2021 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
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Apr 2020 — Sep 2020 [monthly]
Recruiting PHASE1
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Aug 2019 — Apr 2020 [monthly]
Recruiting PHASE1
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May 2019 — Aug 2019 [monthly]
Recruiting PHASE1
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Mar 2019 — May 2019 [monthly]
Recruiting PHASE1
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Nov 2018 — Mar 2019 [monthly]
Recruiting PHASE1
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Jun 2018 — Nov 2018 [monthly]
Recruiting PHASE1
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Oct 2017 — Jun 2018 [monthly]
Recruiting PHASE1
Status: Active Not Recruiting → Recruiting
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Apr 2017 — Oct 2017 [monthly]
Active Not Recruiting PHASE1
Status: Suspended → Active Not Recruiting
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Feb 2017 — Apr 2017 [monthly]
Suspended PHASE1
Status: Recruiting → Suspended
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Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE1
First recorded
Oct 2015
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Children's Oncology Group
- National Cancer Institute (NCI)
For direct contact, visit the study record on ClinicalTrials.gov .