deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 7-arm NCT02348216

Study Evaluating the Safety and Efficacy of KTE-C19 in Adult Participants With Refractory Aggressive Non-Hodgkin Lymphoma (ZUMA-1)

A Phase 1/2 Multicenter Study Evaluating the Safety and Efficacy of KTE-C19 in Adults With Refractory Aggressive Non-Hodgkin Lymphoma

Sponsor: Kite, A Gilead Company

Conditions High Grade B-cell Lymphoma (HGBCL) Primary Mediastinal B-cell Lymphoma (PMBCL) Refractory Diffuse Large B Cell Lymphoma (DLBCL) Relapsed Diffuse Large B-Cell Lymphoma Transformed Follicular Lymphoma (TFL)
Interventions Axicabtagene Ciloleucel Bendamustine Carboplatin Cisplatin Cyclophosphamide Dexamethasone Doxorubicin Etoposide Fludarabine Gemcitabine High-dose methylprednisolone Ifosfamide Levetiracetam Methylprednisolone Oxaliplatin Prednisone Rituximab Tocilizumab Vincristine
Updated 34 times since 2017 Last updated: May 31, 2024 Started: Apr 21, 2015 Primary completion: Jul 27, 2023 Completion: Jul 27, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT02348216, this PHASE1/PHASE2 trial focuses on High Grade B-cell Lymphoma (HGBCL) and Primary Mediastinal B-cell Lymphoma (PMBCL) and remains completed. Sponsored by Kite, A Gilead Company, it has been updated 34 times since 2015, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jun 2017 · 4 months · monthly snapshot~Jun 2017 – ~Sep 2017 · 3 months · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Feb 2018 · 2 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Jan 2019 · 5 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Oct 2020 · 6 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Dec 2021 · 8 months · monthly snapshot~Dec 2021 – ~Jun 2022 · 6 months · monthly snapshot~Jun 2022 – ~Nov 2022 · 5 months · monthly snapshot~Nov 2022 – ~Oct 2023 · 11 months · monthly snapshot~Oct 2023 – ~Jul 2024 · 9 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

34 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE1/PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  4. Oct 2023 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

  5. Nov 2022 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

▶ Show 29 earlier versions

  1. Jun 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  2. Dec 2021 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  3. Apr 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  4. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  5. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  6. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  7. Apr 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  8. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  9. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE1_PHASE2

  10. Nov 2019 — Jan 2020 [monthly]

    Recruiting PHASE1_PHASE2

  11. Aug 2019 — Nov 2019 [monthly]

    Recruiting PHASE1_PHASE2

  12. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1_PHASE2

  13. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

  14. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1_PHASE2

  15. Mar 2019 — May 2019 [monthly]

    Recruiting PHASE1_PHASE2

  16. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1_PHASE2

  17. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1_PHASE2

  18. Aug 2018 — Jan 2019 [monthly]

    Recruiting PHASE1_PHASE2

  19. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1_PHASE2

  20. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1_PHASE2

  21. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

  22. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE1_PHASE2

  23. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE1_PHASE2

  24. Dec 2017 — Feb 2018 [monthly]

    Recruiting PHASE1_PHASE2

  25. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE1_PHASE2

  26. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE1_PHASE2

  27. Jun 2017 — Sep 2017 [monthly]

    Recruiting PHASE1_PHASE2

  28. Feb 2017 — Jun 2017 [monthly]

    Recruiting PHASE1_PHASE2

  29. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Apr 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Kite, A Gilead Company
Data source: Gilead Sciences

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Amsterdam, Netherlands , Boston, United States , Cleveland, United States , Denver, United States , Detroit, United States , Dresden, Germany , Duarte, United States , Essen, Germany , Gilbert, United States , Groningen, Netherlands and 24 more locations