deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT02388906

Efficacy Study of Nivolumab Compared to Ipilimumab in Prevention of Recurrence of Melanoma After Complete Resection of Stage IIIb/c or Stage IV Melanoma (CheckMate 238)

A Phase 3, Randomized, Double-blind Study of Adjuvant Immunotherapy With Nivolumab Versus Ipilimumab After Complete Resection of Stage IIIb/c or Stage IV Melanoma in Subjects Who Are at High Risk for Recurrence (CheckMate 238: CHECKpoint Pathway and nivoluMAb Clinical Trial Evaluation 238)

Sponsor: Bristol-Myers Squibb

Conditions Melanoma
Updated 25 times since 2017 Last updated: Apr 4, 2025 Started: Mar 16, 2015 Primary completion: Nov 26, 2018 Completion: Oct 16, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Melanoma and is currently completed. Bristol-Myers Squibb leads this study, which shows 25 recorded versions since 2015 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Oct 2017 · 8 months · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Feb 2019 · 6 months · monthly snapshot~Feb 2019 – ~Dec 2019 · 10 months · monthly snapshot~Dec 2019 – ~Dec 2020 · 12 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~May 2022 · 8 months · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~May 2023 · 3 months · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Nov 2023 · 5 months · monthly snapshot~Nov 2023 – ~Feb 2024 · 3 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~May 2025 · 4 months · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – present · 9 months · monthly snapshot

Change History

25 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. May 2025 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jan 2025 — May 2025 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  4. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE3

Show 20 earlier versions
  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

  2. Feb 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Nov 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  4. Jun 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  5. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  6. Feb 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  7. Sep 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  8. May 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  9. Sep 2021 — May 2022 [monthly]

    Active Not Recruiting PHASE3

  10. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  11. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  12. Dec 2019 — Dec 2020 [monthly]

    Active Not Recruiting PHASE3

  13. Feb 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE3

  14. Aug 2018 — Feb 2019 [monthly]

    Active Not Recruiting PHASE3

  15. Jul 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE3

  16. Jun 2018 — Jul 2018 [monthly]

    Active Not Recruiting PHASE3

  17. Dec 2017 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  18. Oct 2017 — Dec 2017 [monthly]

    Active Not Recruiting PHASE3

  19. Feb 2017 — Oct 2017 [monthly]

    Active Not Recruiting PHASE3

  20. Jan 2017 — Feb 2017 [monthly]

    Active Not Recruiting PHASE3

    First recorded

Mar 2015

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bristol-Myers Squibb
  • Ono Pharmaceutical Co. Ltd
Data source: Bristol-Myers Squibb

For direct contact, visit the study record on ClinicalTrials.gov .