A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression (TRANSFORM-1)
A Randomized, Double-blind, Multicenter, Active-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Subjects With Treatment-resistant Depression
Sponsor: Janssen Research & Development, LLC
This PHASE3 trial investigates Treatment-resistant Depression and is currently completed. Janssen Research & Development, LLC leads this study, which shows 23 recorded versions since 2015 — indicating substantial longitudinal coverage. This study adds to the longitudinal dataset for psychiatric treatment development.
Status Flow
Change History
23 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE3
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May 2025 — Sep 2025 [monthly]
Completed PHASE3
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Mar 2025 — May 2025 [monthly]
Completed PHASE3
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Sep 2024 — Mar 2025 [monthly]
Completed PHASE3
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Jul 2024 — Sep 2024 [monthly]
Completed PHASE3
▶ Show 18 earlier versions
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Dec 2021 — Jul 2024 [monthly]
Completed PHASE3
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Jan 2021 — Dec 2021 [monthly]
Completed PHASE3
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Jun 2020 — Jan 2021 [monthly]
Completed PHASE3
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May 2019 — Jun 2020 [monthly]
Completed PHASE3
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Mar 2019 — May 2019 [monthly]
Completed PHASE3
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Nov 2018 — Mar 2019 [monthly]
Completed PHASE3
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Oct 2018 — Nov 2018 [monthly]
Completed PHASE3
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Jun 2018 — Oct 2018 [monthly]
Completed PHASE3
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May 2018 — Jun 2018 [monthly]
Completed PHASE3
Status: Active Not Recruiting → Completed
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Mar 2018 — May 2018 [monthly]
Active Not Recruiting PHASE3
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Dec 2017 — Mar 2018 [monthly]
Active Not Recruiting PHASE3
Status: Recruiting → Active Not Recruiting
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Sep 2017 — Dec 2017 [monthly]
Recruiting PHASE3
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Aug 2017 — Sep 2017 [monthly]
Recruiting PHASE3
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Jun 2017 — Aug 2017 [monthly]
Recruiting PHASE3
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May 2017 — Jun 2017 [monthly]
Recruiting PHASE3
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Mar 2017 — May 2017 [monthly]
Recruiting PHASE3
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Feb 2017 — Mar 2017 [monthly]
Recruiting PHASE3
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Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE3
First recorded
Aug 2015
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Janssen Research & Development, LLC
For direct contact, visit the study record on ClinicalTrials.gov .