An Efficacy and Safety Study of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Participants With Higher-Risk Myelodysplastic Syndromes (HR MDS), Chronic Myelomonocytic Leukemia (CMML) and Low-Blast Acute Myelogenous Leukemia (AML)
A Phase 2, Randomized, Controlled, Open-Label, Clinical Study of the Efficacy and Safety of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Patients With Higher-Risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia and Low-Blast Acute Myelogenous Leukemia
Sponsor: Millennium Pharmaceuticals, Inc.
This PHASE2 trial investigates Leukemia, Myeloid, Acute and Leukemia, Myelomonocytic, Chronic and is currently completed. Millennium Pharmaceuticals, Inc. leads this study, which shows 21 recorded versions since 2016 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.
Status Flow
Change History
21 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE2
-
Sep 2024 — Sep 2025 [monthly]
Completed PHASE2
-
Jul 2024 — Sep 2024 [monthly]
Completed PHASE2
-
Sep 2022 — Jul 2024 [monthly]
Completed PHASE2
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Jul 2022 — Sep 2022 [monthly]
Completed PHASE2
▶ Show 16 earlier versions
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Sep 2021 — Jul 2022 [monthly]
Completed PHASE2
Status: Active Not Recruiting → Completed
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Feb 2021 — Sep 2021 [monthly]
Active Not Recruiting PHASE2
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Jan 2021 — Feb 2021 [monthly]
Active Not Recruiting PHASE2
-
Oct 2020 — Jan 2021 [monthly]
Active Not Recruiting PHASE2
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Dec 2019 — Oct 2020 [monthly]
Active Not Recruiting PHASE2
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Dec 2018 — Dec 2019 [monthly]
Active Not Recruiting PHASE2
-
Nov 2018 — Dec 2018 [monthly]
Active Not Recruiting PHASE2
-
Oct 2018 — Nov 2018 [monthly]
Active Not Recruiting PHASE2
-
Jun 2018 — Oct 2018 [monthly]
Active Not Recruiting PHASE2
-
May 2018 — Jun 2018 [monthly]
Active Not Recruiting PHASE2
-
Jan 2018 — May 2018 [monthly]
Active Not Recruiting PHASE2
-
Aug 2017 — Jan 2018 [monthly]
Active Not Recruiting PHASE2
-
Jul 2017 — Aug 2017 [monthly]
Active Not Recruiting PHASE2
Status: Recruiting → Active Not Recruiting
-
Jun 2017 — Jul 2017 [monthly]
Recruiting PHASE2
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Feb 2017 — Jun 2017 [monthly]
Recruiting PHASE2
-
Jan 2017 — Feb 2017 [monthly]
Recruiting PHASE2
First recorded
Apr 2016
Trial started
Per CT.gov start date — pre-dates our first snapshot
Eligibility Summary
No eligibility information available.
Contact Information
- Millennium Pharmaceuticals, Inc.
For direct contact, visit the study record on ClinicalTrials.gov .
Study Locations
Aurora, United States , Badalona, Spain , Baltimore, United States , Barcelona, Spain , Birmingham, United States , Bologna, Italy , Brno, Czechia , Bruges, Belgium , Chapel Hill, United States , Charleroi, Belgium and 42 more locations