deltatrials
Terminated PHASE3 INTERVENTIONAL 2-arm NCT02670083

A Study Evaluating the Efficacy and Safety of Crenezumab Versus Placebo in Participants With Prodromal to Mild Alzheimer's Disease (AD). (CREAD)

A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy And Safety Study of Crenezumab in Patients With Prodromal to Mild Alzheimer's Disease.

Sponsor: Hoffmann-La Roche

Conditions Alzheimer's Disease
Interventions Crenezumab Placebo
Updated 28 times since 2017 Last updated: Jul 1, 2020 Started: Mar 22, 2016 Primary completion: May 31, 2019 Completion: May 31, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

This study was discontinued due to an interim analysis in this study, which indicated that Crenezumab was unlikely to meet its primary endpoint.

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Listed as NCT02670083, this PHASE3 trial focuses on Alzheimer's Disease and remains terminated or withdrawn. Sponsored by Hoffmann-La Roche, it has been updated 28 times since 2016, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Aug 2017 · 3 months · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Aug 2020 · 10 months · monthly snapshot~Aug 2020 – ~Nov 2020 · 3 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 9 months · monthly snapshot

Change History

28 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE3

  4. Dec 2021 — Jul 2024 [monthly]

    Terminated PHASE3

  5. Jan 2021 — Dec 2021 [monthly]

    Terminated PHASE3

▶ Show 23 earlier versions

  1. Nov 2020 — Jan 2021 [monthly]

    Terminated PHASE3

  2. Aug 2020 — Nov 2020 [monthly]

    Terminated PHASE3

    Status: Completed → Terminated

  3. Oct 2019 — Aug 2020 [monthly]

    Completed PHASE3

  4. Jul 2019 — Oct 2019 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  5. Apr 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE3

  6. Feb 2019 — Apr 2019 [monthly]

    Active Not Recruiting PHASE3

  7. Dec 2018 — Feb 2019 [monthly]

    Active Not Recruiting PHASE3

  8. Nov 2018 — Dec 2018 [monthly]

    Active Not Recruiting PHASE3

  9. Oct 2018 — Nov 2018 [monthly]

    Active Not Recruiting PHASE3

  10. Sep 2018 — Oct 2018 [monthly]

    Active Not Recruiting PHASE3

  11. Aug 2018 — Sep 2018 [monthly]

    Active Not Recruiting PHASE3

  12. Jun 2018 — Aug 2018 [monthly]

    Active Not Recruiting PHASE3

  13. Mar 2018 — Jun 2018 [monthly]

    Active Not Recruiting PHASE3

  14. Feb 2018 — Mar 2018 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  15. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE3

  16. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE3

  17. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  18. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  19. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  20. May 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

  21. Apr 2017 — May 2017 [monthly]

    Recruiting PHASE3

  22. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE3

  23. Jan 2017 — Feb 2017 [monthly]

    Recruiting PHASE3

    First recorded

Mar 2016

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aarhus N, Denmark , Albacete, Spain , Albany, United States , Amadora, Portugal , Amherst, United States , Ankara, Turkey (Türkiye) , Atlanta, United States , Auburn, United States , Austin, United States , BArcelon, Spain and 154 more locations