deltatrials
Terminated PHASE3 INTERVENTIONAL 2-arm NCT03114657

A Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mild Alzheimer's Disease (AD) (CREAD 2)

A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Efficacy and Safety Study of Crenezumab in Patients With Prodromal to Mild Alzheimer's Disease

Sponsor: Hoffmann-La Roche

Conditions Alzheimer's Disease
Interventions Crenezumab Placebo
Updated 27 times since 2017 Last updated: Jul 1, 2020 Started: Mar 29, 2017 Primary completion: Jun 11, 2019 Completion: Jun 11, 2019
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

This study was discontinued due to an interim analysis in the BN29552 study, which indicated that Crenezumab was unlikely to meet its primary endpoint.

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This PHASE3 trial investigates Alzheimer's Disease and is currently terminated or withdrawn. Hoffmann-La Roche leads this study, which shows 27 recorded versions since 2017 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Feb 2018 · 3 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Apr 2019 · 5 months · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Nov 2019 · 3 months · monthly snapshot~Nov 2019 – ~Aug 2020 · 9 months · monthly snapshot~Aug 2020 – ~Nov 2020 · 3 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshot~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE3

  4. Dec 2021 — Jul 2024 [monthly]

    Terminated PHASE3

  5. Jan 2021 — Dec 2021 [monthly]

    Terminated PHASE3

▶ Show 22 earlier versions

  1. Nov 2020 — Jan 2021 [monthly]

    Terminated PHASE3

  2. Aug 2020 — Nov 2020 [monthly]

    Terminated PHASE3

    Status: Completed → Terminated

  3. Nov 2019 — Aug 2020 [monthly]

    Completed PHASE3

  4. Aug 2019 — Nov 2019 [monthly]

    Completed PHASE3

  5. Jul 2019 — Aug 2019 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  6. May 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  7. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  8. Nov 2018 — Apr 2019 [monthly]

    Recruiting PHASE3

  9. Sep 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  10. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  11. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  12. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  13. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  14. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE3

  15. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

  16. Nov 2017 — Feb 2018 [monthly]

    Recruiting PHASE3

  17. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

  18. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  19. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  20. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

  21. Jun 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

  22. May 2017 — Jun 2017 [monthly]

    Recruiting PHASE3

    First recorded

Mar 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aarhus N, Denmark , Aichi, Japan , Albacete, Spain , Ankara, Turkey (Türkiye) , Atlantis, United States , Austin, United States , BArcelon, Spain , Barakaldo, Spain , Barcelona, Spain , Beaumont, United States and 175 more locations