deltatrials
Completed PHASE2 INTERVENTIONAL 3-arm NCT03977584

Tau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Placebo in Preclinical Presenilin1 (PSEN1) E280A Mutation Carriers in the Treatment of Autosomal-Dominant Alzheimer's Disease

Tau PET Longitudinal Substudy Associated With: A Double-Blind, Placebo-Controlled Parallel-Group Study in Preclinical PSEN1 E280A Mutation Carriers Randomized to Crenezumab or Placebo, and in Non-randomized, Placebo-treated Non-carriers From the Same Kindred, to Evaluate the Efficacy and Safety of Crenezumab in the Treatment of Autosomal-Dominant Alzheimer's Disease

Sponsor: Banner Alzheimer's Institute

Conditions Alzheimer Disease
Interventions Crenezumab Placebo [^18F]GTP1
Updated 35 times since 2019 Last updated: Mar 13, 2024 Started: Jun 10, 2019 Primary completion: Apr 19, 2022 Completion: Apr 19, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Alzheimer Disease, this trial is completed. The trial is conducted by Banner Alzheimer's Institute and has accumulated 35 data snapshots since 2019. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jul 2019 – ~Dec 2019 · 5 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~May 2023 · 11 months · monthly snapshot~May 2023 – ~Apr 2024 · 11 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

35 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Apr 2024 — Jul 2024 [monthly]

    Completed PHASE2

  5. May 2023 — Apr 2024 [monthly]

    Completed PHASE2

▶ Show 30 earlier versions

  1. Jun 2022 — May 2023 [monthly]

    Completed PHASE2

    Status: Recruiting → Completed

  2. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  3. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE2

  4. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE2

  5. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE2

  6. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE2

  7. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE2

  8. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  9. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  10. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  11. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  12. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  13. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  14. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  15. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  16. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  17. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  18. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  19. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  20. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  21. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  22. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  23. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  24. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  25. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2

  26. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  27. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  28. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  29. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  30. Jul 2019 — Dec 2019 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Jun 2019

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Banner Alzheimer's Institute
  • Hoffmann-La Roche
  • National Institute on Aging (NIA)
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations