deltatrials
Active Not Recruiting NA INTERVENTIONAL 2-arm NCT02926911

Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS (COMET)

Comparing an Operation to Monitoring, With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS: A Phase III Prospective Randomized Trial

Sponsor: Alliance Foundation Trials, LLC.

Conditions DCIS Ductal Carcinoma in Situ
Interventions Active Monitoring Surgery
Updated 41 times since 2017 Last updated: Jan 8, 2026 Started: Feb 22, 2017 Primary completion: Jun 27, 2024 Completion: Jul 31, 2030
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This NA trial investigates DCIS and Ductal Carcinoma in Situ and is currently ongoing. Alliance Foundation Trials, LLC. leads this study, which shows 41 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Apr 2017 · 3 months · monthly snapshot~Apr 2017 – ~Jun 2017 · 2 months · monthly snapshot~Jun 2017 – ~Sep 2017 · 3 months · monthly snapshot~Sep 2017 – ~Nov 2017 · 2 months · monthly snapshot~Nov 2017 – ~Jan 2018 · 2 months · monthly snapshot~Jan 2018 – ~Apr 2018 · 3 months · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Mar 2019 · 5 months · monthly snapshot~Mar 2019 – ~Jul 2019 · 4 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Jan 2022 · 2 months · monthly snapshot~Jan 2022 – ~Sep 2022 · 8 months · monthly snapshot~Sep 2022 – ~Mar 2023 · 6 months · monthly snapshot~Mar 2023 – ~May 2023 · 2 months · monthly snapshot~May 2023 – ~Jul 2023 · 2 months · monthly snapshot~Jul 2023 – ~Oct 2023 · 3 months · monthly snapshot~Oct 2023 – ~Feb 2024 · 4 months · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Jul 2025 · 4 months · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Feb 2026 · 5 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

41 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting NA

  2. Sep 2025 — Feb 2026 [monthly]

    Active Not Recruiting NA

  3. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting NA

  4. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting NA

  5. Mar 2025 — Jul 2025 [monthly]

    Active Not Recruiting NA

▶ Show 36 earlier versions

  1. Sep 2024 — Mar 2025 [monthly]

    Active Not Recruiting NA

  2. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting NA

  3. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting NA

  4. Feb 2024 — Apr 2024 [monthly]

    Active Not Recruiting NA

  5. Oct 2023 — Feb 2024 [monthly]

    Active Not Recruiting NA

  6. Jul 2023 — Oct 2023 [monthly]

    Active Not Recruiting NA

  7. May 2023 — Jul 2023 [monthly]

    Active Not Recruiting NA

    Status: Recruiting → Active Not Recruiting

  8. Mar 2023 — May 2023 [monthly]

    Recruiting NA

  9. Sep 2022 — Mar 2023 [monthly]

    Recruiting NA

  10. Jan 2022 — Sep 2022 [monthly]

    Recruiting NA

  11. Nov 2021 — Jan 2022 [monthly]

    Recruiting NA

  12. Sep 2021 — Nov 2021 [monthly]

    Recruiting NA

  13. May 2021 — Sep 2021 [monthly]

    Recruiting NA

  14. Jan 2021 — May 2021 [monthly]

    Recruiting NA

  15. Dec 2020 — Jan 2021 [monthly]

    Recruiting NA

  16. Oct 2020 — Dec 2020 [monthly]

    Recruiting NA

  17. Aug 2020 — Oct 2020 [monthly]

    Recruiting NA

  18. Jun 2020 — Aug 2020 [monthly]

    Recruiting NA

  19. May 2020 — Jun 2020 [monthly]

    Recruiting NA

  20. Feb 2020 — May 2020 [monthly]

    Recruiting NA

  21. Dec 2019 — Feb 2020 [monthly]

    Recruiting NA

  22. Oct 2019 — Dec 2019 [monthly]

    Recruiting NA

  23. Aug 2019 — Oct 2019 [monthly]

    Recruiting NA

  24. Jul 2019 — Aug 2019 [monthly]

    Recruiting NA

  25. Mar 2019 — Jul 2019 [monthly]

    Recruiting NA

  26. Oct 2018 — Mar 2019 [monthly]

    Recruiting NA

  27. Sep 2018 — Oct 2018 [monthly]

    Recruiting NA

  28. Jul 2018 — Sep 2018 [monthly]

    Recruiting NA

  29. Jun 2018 — Jul 2018 [monthly]

    Recruiting NA

  30. Apr 2018 — Jun 2018 [monthly]

    Recruiting NA

  31. Jan 2018 — Apr 2018 [monthly]

    Recruiting NA

  32. Nov 2017 — Jan 2018 [monthly]

    Recruiting NA

  33. Sep 2017 — Nov 2017 [monthly]

    Recruiting NA

  34. Jun 2017 — Sep 2017 [monthly]

    Recruiting NA

  35. Apr 2017 — Jun 2017 [monthly]

    Recruiting NA

    Status: Not Yet Recruiting → Recruiting

  36. Jan 2017 — Apr 2017 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Alliance Foundation Trials, LLC.
  • Breast Cancer Research Foundation
  • Dana-Farber Cancer Institute
  • Duke University
  • M.D. Anderson Cancer Center
  • New York University
  • Patient-Centered Outcomes Research Institute
  • Rising Tide Foundation
  • Washington University School of Medicine
Data source: Alliance Foundation Trials, LLC.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Albuquerque, United States , Anaconda, United States , Anchorage, United States , Ann Arbor, United States , Annapolis, United States , Appleton, United States , Baltimore, United States , Baton Rouge, United States , Bellevue, United States , Belpre, United States and 107 more locations