deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT02929329

Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction (GALACTIC-HF)

A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects With Chronic Heart Failure With Reduced Ejection Fraction (GALACTIC-HF)

Sponsor: Cytokinetics

Conditions Heart Failure
Interventions Omecamtiv Mecarbil Placebo Standard of Care
Updated 33 times since 2017 Last updated: Nov 2, 2021 Started: Jan 6, 2017 Primary completion: Sep 14, 2020 Completion: Sep 14, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Heart Failure and is currently completed. Cytokinetics leads this study, which shows 33 recorded versions since 2017 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Jul 2017 · 5 months · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Nov 2017 · 2 months · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Mar 2018 · 3 months · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Dec 2019 · 4 months · monthly snapshot~Dec 2019 – ~May 2020 · 5 months · monthly snapshot~May 2020 – ~Sep 2020 · 4 months · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Jul 2024 · 31 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – present · 8 months · monthly snapshot

Change History

33 versions recorded

  1. Nov 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2025 — Nov 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Dec 2021 — Jul 2024 [monthly]

    Completed PHASE3

▶ Show 28 earlier versions

  1. Sep 2021 — Dec 2021 [monthly]

    Completed PHASE3

  2. Jan 2021 — Sep 2021 [monthly]

    Completed PHASE3

  3. Nov 2020 — Jan 2021 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  4. Sep 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  5. May 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  6. Dec 2019 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  7. Aug 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  8. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  9. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  10. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  11. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  12. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  13. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  14. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  15. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  16. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  17. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  18. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  19. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  20. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  21. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE3

  22. Dec 2017 — Mar 2018 [monthly]

    Recruiting PHASE3

  23. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  24. Sep 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

  25. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  26. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

  27. Feb 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  28. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Cytokinetics
Data source: Cytokinetics

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

's-Hertogenbosch, Netherlands , A Coruña, Spain , Aalborg, Denmark , Aalst, Belgium , Aarhus N, Denmark , Abington, United States , Adana, Turkey (Türkiye) , Afyonkarahisar, Turkey (Türkiye) , Ageo-shi, Japan , Aguascalientes, Mexico and 790 more locations