deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT03759392

Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure (METEORIC-HF)

A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure With Reduced Ejection Fraction and Decreased Exercise Tolerance

Sponsor: Cytokinetics

Conditions Heart Failure With Reduced Ejection Fraction
Interventions Omecamtiv Mecarbil Placebo
Updated 27 times since 2018 Last updated: Feb 11, 2023 Started: Apr 9, 2019 Primary completion: Nov 8, 2021 Completion: Jan 6, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03759392, this PHASE3 trial focuses on Heart Failure With Reduced Ejection Fraction and remains completed. Sponsored by Cytokinetics, it has been updated 27 times since 2019, reflecting substantial change activity. This study contributes longitudinal data to the cardiovascular research landscape.

Status Flow

~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Apr 2020 · 4 months · monthly snapshot~Apr 2020 – ~Jul 2020 · 3 months · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Sep 2021 · 6 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Feb 2022 · 4 months · monthly snapshot~Feb 2022 – ~Apr 2023 · 14 months · monthly snapshot~Apr 2023 – ~Jul 2024 · 15 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Apr 2023 — Jul 2024 [monthly]

    Completed PHASE3

  5. Feb 2022 — Apr 2023 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

▶ Show 22 earlier versions

  1. Oct 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  2. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  3. Mar 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  4. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  5. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  6. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  7. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

  8. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  9. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  10. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  11. Apr 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  12. Dec 2019 — Apr 2020 [monthly]

    Recruiting PHASE3

  13. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  14. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  15. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  16. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  17. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  18. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  19. Apr 2019 — May 2019 [monthly]

    Not Yet Recruiting PHASE3

  20. Feb 2019 — Apr 2019 [monthly]

    Not Yet Recruiting PHASE3

  21. Jan 2019 — Feb 2019 [monthly]

    Not Yet Recruiting PHASE3

  22. Dec 2018 — Jan 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Cytokinetics
Data source: Cytokinetics

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

's-Hertogenbosch, Netherlands , Amsterdam, Netherlands , Anchorage, United States , Ann Arbor, United States , Atlanta, United States , Bad Nauheim, Germany , Balatonfüred, Hungary , Baltimore, United States , Bayonne, France , Bialystok, Poland and 67 more locations