deltatrials
Terminated PHASE3 INTERVENTIONAL 1-arm NCT03068130

Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension RANGER (RANGER)

An Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertension

Sponsor: Biogen

Interventions Bardoxolone methyl
Updated 19 times since 2017 Last updated: May 26, 2025 Started: Apr 18, 2017 Primary completion: Sep 30, 2020 Completion: Sep 30, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

The company determined that continued exposure of these high-risk PH patients to clinic or in-person visits during the COVID pandemic presented an unacceptable risk.

This PHASE3 trial investigates Pulmonary Hypertension and is currently terminated or withdrawn. Biogen leads this study, which shows 19 recorded versions since 2017 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

~Mar 2017 – ~May 2017 · 2 months · monthly snapshot~May 2017 – ~Aug 2017 · 3 months · monthly snapshot~Aug 2017 – ~Jun 2018 · 10 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Oct 2018 · 3 months · monthly snapshot~Oct 2018 – ~Sep 2019 · 11 months · monthly snapshot~Sep 2019 – ~Jun 2020 · 9 months · monthly snapshot~Jun 2020 – ~Sep 2020 · 3 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Apr 2022 · 4 months · monthly snapshot~Apr 2022 – ~Nov 2023 · 19 months · monthly snapshot~Nov 2023 – ~Mar 2024 · 4 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

19 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Jul 2025 — Sep 2025 [monthly]

    Terminated PHASE3

  3. Sep 2024 — Jul 2025 [monthly]

    Terminated PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE3

  5. Mar 2024 — Jul 2024 [monthly]

    Terminated PHASE3

Show 14 earlier versions
  1. Nov 2023 — Mar 2024 [monthly]

    Terminated PHASE3

  2. Apr 2022 — Nov 2023 [monthly]

    Terminated PHASE3

  3. Dec 2021 — Apr 2022 [monthly]

    Terminated PHASE3

  4. Oct 2021 — Dec 2021 [monthly]

    Terminated PHASE3

  5. Jan 2021 — Oct 2021 [monthly]

    Terminated PHASE3

    Status: Active Not RecruitingTerminated

  6. Sep 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  7. Jun 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  8. Sep 2019 — Jun 2020 [monthly]

    Recruiting PHASE3

  9. Oct 2018 — Sep 2019 [monthly]

    Recruiting PHASE3

  10. Jul 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  11. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  12. Aug 2017 — Jun 2018 [monthly]

    Recruiting PHASE3

  13. May 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  14. Mar 2017 — May 2017 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Biogen
Data source: Biogen

For direct contact, visit the study record on ClinicalTrials.gov .