deltatrials
Terminated PHASE1 INTERVENTIONAL 2-arm NCT03199040

Neoantigen DNA Vaccine Alone vs. Neoantigen DNA Vaccine Plus Durvalumab in Triple Negative Breast Cancer Patients Following Standard of Care Therapy

A Randomized Phase 1 Trial of Neoantigen DNA Vaccine Alone vs. Neoantigen DNA Vaccine Plus Durvalumab in Triple Negative Breast Cancer Patients Following Standard of Care Therapy

Sponsor: MedImmune LLC

Conditions TNBC - Triple-Negative Breast Cancer Triple Negative Breast Cancer Triple Negative Breast Neoplasms Triple-negative Breast Carcinoma
Interventions Durvalumab Neoantigen DNA vaccine Peripheral blood draw TDS-IM system (Inchor Medical Systems)
Updated 27 times since 2017 Last updated: Apr 25, 2024 Started: Jul 23, 2019 Primary completion: Nov 21, 2022 Completion: May 1, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Drugs/equipment unavailable and insufficient funding

Other terminated trials from MedImmune LLC

More terminations from MedImmune LLC

Listed as NCT03199040, this PHASE1 trial focuses on TNBC - Triple-Negative Breast Cancer and Triple Negative Breast Cancer and remains terminated or withdrawn. Sponsored by MedImmune LLC, it has been updated 27 times since 2019, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Aug 2017 – ~May 2018 · 9 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Nov 2018 · 3 months · monthly snapshot~Nov 2018 – ~Jul 2019 · 8 months · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Feb 2020 · 4 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~Jul 2020 · 3 months · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Sep 2021 · 7 months · monthly snapshot~Sep 2021 – ~Jan 2022 · 4 months · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Sep 2022 · 5 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~May 2023 · 4 months · monthly snapshot~May 2023 – ~Jul 2023 · 2 months · monthly snapshot~Jul 2023 – ~Jan 2024 · 6 months · monthly snapshot~Jan 2024 – ~Jun 2024 · 5 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 8 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE1

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  4. Jun 2024 — Jul 2024 [monthly]

    Terminated PHASE1

  5. Jan 2024 — Jun 2024 [monthly]

    Terminated PHASE1

    Status: Active Not Recruiting → Terminated

▶ Show 22 earlier versions

  1. Jul 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE1

  2. May 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1

  3. Jan 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  4. Sep 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  5. Apr 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  6. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  7. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  8. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE1

  9. Sep 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  10. Feb 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  11. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  12. Aug 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  13. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  14. Apr 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  15. Feb 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  16. Oct 2019 — Feb 2020 [monthly]

    Recruiting PHASE1

  17. Jul 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  18. Nov 2018 — Jul 2019 [monthly]

    Recruiting PHASE1

  19. Aug 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  20. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  21. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  22. Aug 2017 — May 2018 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • MedImmune LLC
  • National Cancer Institute (NCI)
  • National Institutes of Health (NIH)
  • Washington University School of Medicine
Data source: Washington University School of Medicine

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations