deltatrials
Completed PHASE1 INTERVENTIONAL 1-arm NCT03524170

Radiation Therapy and M7824 in Treating Patients With Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer

RACHEL1: A Phase I Radiation and Checkpoint Blockade Trial in Patients With Metastatic Hormone Receptor Positive, HER2 Negative Breast Cancer

Sponsor: M.D. Anderson Cancer Center

Conditions Anatomic Stage IV Breast Cancer AJCC v8 Metastatic Breast Carcinoma Prognostic Stage IV Breast Cancer AJCC v8
Interventions Bintrafusp Alfa Radiation Therapy
Updated 14 times since 2018 Last updated: Mar 3, 2022 Started: Apr 30, 2018 Primary completion: Feb 10, 2022 Completion: Feb 10, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1 clinical study on Anatomic Stage IV Breast Cancer AJCC v8 and Metastatic Breast Carcinoma, this trial is completed. The trial is conducted by M.D. Anderson Cancer Center and has accumulated 14 data snapshots since 2018. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshot~Sep 2018 – ~Jun 2019 · 9 months · monthly snapshot~Jun 2019 – ~Dec 2019 · 6 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Jun 2020 · 5 months · monthly snapshot~Jun 2020 – ~Nov 2020 · 5 months · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Apr 2022 · 7 months · monthly snapshot~Apr 2022 – ~Jul 2024 · 27 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 24 months · monthly snapshot

Change History

14 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Apr 2022 — Jul 2024 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  4. Sep 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  5. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

▶ Show 9 earlier versions

  1. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  2. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  3. Jun 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  4. Jan 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  5. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  6. Jun 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  7. Sep 2018 — Jun 2019 [monthly]

    Recruiting PHASE1

  8. Jul 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  9. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

    First recorded

Apr 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • M.D. Anderson Cancer Center
Data source: M.D. Anderson Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations