deltatrials
Active Not Recruiting PHASE3 INTERVENTIONAL 15-arm NCT03533582

Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

Pediatric Hepatic Malignancy International Therapeutic Trial (PHITT)

Sponsor: Children's Oncology Group

Conditions Childhood Hepatocellular Carcinoma Childhood Malignant Liver Neoplasm Fibrolamellar Carcinoma Hepatoblastoma Hepatocellular Malignant Neoplasm, Not Otherwise Specified
Interventions Biospecimen Collection Carboplatin Cisplatin Doxorubicin Etoposide Fluorouracil Gemcitabine Irinotecan Oxaliplatin Patient Observation Resection Sorafenib Vincristine Sulfate
Updated 54 times since 2018 Last updated: Dec 18, 2025 Started: May 24, 2018 Primary completion: Dec 31, 2026 Completion: Dec 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03533582, this PHASE3 trial focuses on Childhood Hepatocellular Carcinoma and Childhood Malignant Liver Neoplasm and remains ongoing. Sponsored by Children's Oncology Group, it has been updated 54 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Feb 2019 · 5 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jul 2019 · 3 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Mar 2022 · 5 months · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Sep 2023 · 3 months · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Mar 2025 · 59 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Jul 2025 · 3 months · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Jan 2026 · 3 months · monthly snapshot~Jan 2026 – present · 4 months · monthly snapshot

Change History

54 versions recorded

  1. Jan 2026 — Present [monthly]

    Active Not Recruiting PHASE3

  2. Oct 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE3

  3. Sep 2025 — Oct 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Jul 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE3

▶ Show 49 earlier versions

  1. Apr 2025 — Jul 2025 [monthly]

    Active Not Recruiting PHASE3

  2. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE3

  3. Jan 2025 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  4. Nov 2024 — Jan 2025 [monthly]

    Active Not Recruiting PHASE3

    Phase: PHASE2/PHASE3 → PHASE3

  5. Oct 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2/PHASE3

  6. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2/PHASE3

  7. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2/PHASE3

    Phase: PHASE2_PHASE3 → PHASE2/PHASE3

  8. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  9. Mar 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  10. Feb 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE2_PHASE3

    Status: Recruiting → Active Not Recruiting

  11. Dec 2023 — Feb 2024 [monthly]

    Recruiting PHASE2_PHASE3

  12. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE2_PHASE3

  13. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE2_PHASE3

  14. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE2_PHASE3

  15. Jun 2023 — Sep 2023 [monthly]

    Recruiting PHASE2_PHASE3

  16. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE2_PHASE3

  17. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE2_PHASE3

  18. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE2_PHASE3

  19. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE2_PHASE3

  20. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE2_PHASE3

  21. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2_PHASE3

  22. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE2_PHASE3

  23. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2_PHASE3

  24. Apr 2022 — Jun 2022 [monthly]

    Recruiting PHASE2_PHASE3

  25. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE2_PHASE3

  26. Oct 2021 — Mar 2022 [monthly]

    Recruiting PHASE2_PHASE3

  27. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2_PHASE3

  28. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2_PHASE3

  29. Apr 2021 — Jun 2021 [monthly]

    Recruiting PHASE2_PHASE3

  30. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2_PHASE3

  31. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE2_PHASE3

  32. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2_PHASE3

  33. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE2_PHASE3

  34. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE2_PHASE3

  35. Jul 2020 — Sep 2020 [monthly]

    Recruiting PHASE2_PHASE3

  36. May 2020 — Jul 2020 [monthly]

    Recruiting PHASE2_PHASE3

  37. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2_PHASE3

  38. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2_PHASE3

  39. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE2_PHASE3

  40. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2_PHASE3

  41. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE2_PHASE3

  42. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2_PHASE3

  43. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2_PHASE3

  44. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2_PHASE3

  45. Apr 2019 — Jul 2019 [monthly]

    Recruiting PHASE2_PHASE3

  46. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2_PHASE3

  47. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2_PHASE3

  48. Sep 2018 — Feb 2019 [monthly]

    Recruiting PHASE2_PHASE3

  49. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE2_PHASE3

    First recorded

May 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Children's Oncology Group
  • National Cancer Institute (NCI)
Data source: Children's Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Albany, United States , Albuquerque, United States , Allentown, United States , Anchorage, United States , Ann Arbor, United States , Asheville, United States , Atlanta, United States , Augusta, United States , Aurora, United States and 146 more locations