deltatrials
Completed EARLY_PHASE1 INTERVENTIONAL 2-arm NCT03755102

A Pilot Study of Dacomitinib With or Without Osimertinib for Patients With Metastatic EGFR Mutant Lung Cancers With Disease Progression on Osimertinib.

A Pilot Study of Dacomitinib With or Without Osimertinib for Patients With Metastatic EGFR Mutant Lung Cancers With Disease Progressionon Osimertinib.

Sponsor: Memorial Sloan Kettering Cancer Center

Updated 15 times since 2018 Last updated: May 12, 2025 Started: Nov 21, 2018 Primary completion: Jul 7, 2023 Completion: Jul 7, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03755102, this EARLY_PHASE1 trial focuses on EGFR Gene Mutation and Lung Cancer and remains completed. Sponsored by Memorial Sloan Kettering Cancer Center, it has been updated 15 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Dec 2018 – ~May 2019 · 5 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~May 2020 · 7 months · monthly snapshot~May 2020 – ~Jan 2021 · 8 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Sep 2021 · 6 months · monthly snapshot~Sep 2021 – ~Sep 2022 · 12 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Aug 2023 · 8 months · monthly snapshot~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshot~Jun 2025 – present · 14 months · monthly snapshot

Change History

15 versions recorded
  1. Jun 2025 — Present [monthly]

    Completed EARLY_PHASE1

  2. Sep 2024 — Jun 2025 [monthly]

    Completed EARLY_PHASE1

  3. Jul 2024 — Sep 2024 [monthly]

    Completed EARLY_PHASE1

  4. Aug 2023 — Jul 2024 [monthly]

    Completed EARLY_PHASE1

    Status: Active Not RecruitingCompleted

  5. Dec 2022 — Aug 2023 [monthly]

    Active Not Recruiting EARLY_PHASE1

    Status: RecruitingActive Not Recruiting

Show 10 earlier versions
  1. Sep 2022 — Dec 2022 [monthly]

    Recruiting EARLY_PHASE1

  2. Sep 2021 — Sep 2022 [monthly]

    Recruiting EARLY_PHASE1

  3. Mar 2021 — Sep 2021 [monthly]

    Recruiting EARLY_PHASE1

  4. Jan 2021 — Mar 2021 [monthly]

    Recruiting EARLY_PHASE1

  5. May 2020 — Jan 2021 [monthly]

    Recruiting EARLY_PHASE1

  6. Oct 2019 — May 2020 [monthly]

    Recruiting EARLY_PHASE1

  7. Jul 2019 — Oct 2019 [monthly]

    Recruiting EARLY_PHASE1

  8. Jun 2019 — Jul 2019 [monthly]

    Recruiting EARLY_PHASE1

  9. May 2019 — Jun 2019 [monthly]

    Recruiting EARLY_PHASE1

  10. Dec 2018 — May 2019 [monthly]

    Recruiting EARLY_PHASE1

    First recorded

Nov 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Memorial Sloan Kettering Cancer Center
Data source: Memorial Sloan Kettering Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .